"Astaxanthin is 6000 times stronger than vitamin C, 550 times stronger than vitamin E, and 40 times stronger than beta-carotene."
Dr. Mark Hyman, a practicing family physician and internationally recognized leader in Functional Medicine
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ASTAXANTHIN & LONGEVITY
Astaxanthin, often hailed as the "queen of antioxidants," is 6000 times more powerful than Vitamin C, offering unmatched protection against oxidative stress to support cellular health, vibrant skin, and lasting longevity.
Astaxanthin: The “Queen of Antioxidants” and Its Role in Longevity and Health
Astaxanthin, often referred to as the "king of carotenoids," is gaining recognition as one of nature's most potent antioxidants. This vibrant red pigment, found in microalgae, krill, and salmon, is renowned for its ability to combat oxidative stress, support cellular health, and promote longevity.
Astaxanthin’s antioxidant capacity is what makes it a standout. Studies show that it is up to 6000 times more potent than vitamin C, 800 times stronger than CoQ10, and 550 times more effective than vitamin E in neutralizing free radicals (Nishida et al., 2007). This unparalleled ability to combat oxidative stress is crucial for slowing cellular aging and maintaining overall health.
Aging is closely tied to oxidative stress, a process where an imbalance between free radicals and antioxidants leads to cellular damage. Over time, this damage contributes to chronic diseases, inflammation, and the visible signs of aging. Astaxanthin stands out as a superior antioxidant, offering benefits that go beyond standard dietary supplements like vitamin C or vitamin E.
Backed by scientific research, astaxanthin offers a wide array of health benefits that extend across skin health, cardiovascular protection, cognitive function, and beyond. Let’s dive into the mechanisms that make astaxanthin a powerhouse for health and longevity.
Key Mechanisms of Astaxanthin
Protecting Cellular Integrity: Astaxanthin is unique among antioxidants in that it spans the cell membrane, protecting both the water- and lipid-soluble parts of the cell. This structural advantage makes it highly effective in reducing lipid peroxidation and preserving mitochondrial function—critical for energy production and cellular repair (McAllister et al., 2021).
Reducing Chronic Inflammation: Chronic, low-grade inflammation accelerates the aging process and contributes to diseases such as arthritis, cardiovascular disease, and neurodegeneration. Astaxanthin has been shown to inhibit pro-inflammatory cytokines like TNF-α and IL-6, reducing systemic inflammation and supporting healthier aging (Pereira et al., 2020).
Enhancing Mitochondrial Function: Mitochondria, the powerhouses of the cell, play a pivotal role in energy production and metabolic health. Astaxanthin protects mitochondrial membranes from oxidative damage, ensuring efficient energy generation and slowing the decline in cellular function associated with aging (Waldman, 2024).
Promoting DNA Repair: DNA damage caused by oxidative stress is a key driver of aging and age-related diseases. Astaxanthin has been shown to enhance DNA repair mechanisms, reducing the accumulation of mutations over time and supporting cellular health (Park et al., 2010).
Longevity Genes and Cellular Mechanisms: FOXO3, SIRT1, and Nrf2
Astaxanthin influences various cellular mechanisms linked to longevity, including pathways like FOXO3, SIRT1, and Nrf2, which are associated with stress resistance, metabolic regulation, and DNA repair. These pathways play essential roles in cell survival, autophagy (the process of cellular cleanup), and inflammation control, all of which are critical for promoting a longer, healthier life.
FOXO3 Activation: FOXO3, a longevity-associated gene, is known for its role in cellular repair and stress resilience. Astaxanthin has been shown to stimulate FOXO3, contributing to its longevity effects. (Sorrenti, 2020)
SIRT1 Modulation: SIRT1, commonly referred to as a "longevity gene," regulates aging processes by controlling metabolic functions and promoting cellular repair. Astaxanthin's potential to modulate SIRT1 may enhance its anti-aging benefits. (Sorrenti, 2020)
Nrf2 Pathway: This pathway plays a crucial role in antioxidant defense, helping cells counteract oxidative stress. By activating Nrf2, astaxanthin boosts the body’s ability to combat environmental stressors and protect cellular integrity. (Sorrenti, 2020)
Astaxanthin’s influence on longevity genes and pathways—FOXO3, SIRT1, and Nrf2—underscores its role as a potent nutraceutical for promoting healthy aging. By activating these key regulators, astaxanthin supports cellular repair, enhances antioxidant defenses, and improves resilience to metabolic and oxidative stress.
Health Benefits of Astaxanthin
Cardiovascular Support: Astaxanthin improves lipid profiles by reducing LDL cholesterol and increasing HDL cholesterol. It also protects endothelial cells, reducing the risk of atherosclerosis and supporting heart health (Choi et al., 2011).
Cognitive Health: As a neuroprotective agent, astaxanthin crosses the blood-brain barrier to combat oxidative stress in the brain. It has been shown to improve memory, support neural plasticity, and reduce the risk of neurodegenerative conditions such as Alzheimer’s disease (Grimmig et al., 2017).
Eye Health: Astaxanthin supports vision by reducing oxidative damage to the retina and protecting against age-related macular degeneration (AMD). It also alleviates eye fatigue, a common issue in today’s screen-dominated world (Donoso et al., 2021).
Astaxanthin and Sports Performance: A Game-Changer for Athletes
Athletes and fitness enthusiasts are always seeking ways to enhance performance and recovery, and astaxanthin has emerged as a standout supplement in the sports nutrition world. Its potent antioxidant and anti-inflammatory properties address two critical challenges in athletic performance: oxidative stress and muscle recovery.
Boosting Endurance and Energy: Astaxanthin supports mitochondrial health by reducing oxidative damage and enhancing energy production, making it an effective ergogenic aid for endurance activities. A study on young athletes demonstrated improved cycling and running performance, with reduced heart rates during submaximal exertion (Waldman, 2024). This indicates astaxanthin’s ability to optimize energy utilization and reduce fatigue during prolonged exercise.
Reducing Muscle Damage and Enhancing Recovery: Strenuous exercise induces muscle damage and inflammation, often leading to delayed onset muscle soreness (DOMS). Astaxanthin has been shown to decrease levels of muscle enzymes like creatine kinase (CK) and aspartate aminotransferase (AST), both markers of muscle damage. This effect translates to faster recovery times and reduced post-exercise soreness (Djordjevic et al., 2012).
Combating Exercise-Induced Oxidative Stress: During high-intensity workouts, reactive oxygen species (ROS) levels increase, leading to oxidative stress that can impair performance and recovery. Astaxanthin’s ability to neutralize ROS and increase antioxidant defenses, such as glutathione and superoxide dismutase (SOD), has been demonstrated in studies on athletes (McAllister et al., 2021).
For athletes aiming to push boundaries while safeguarding their health, astaxanthin provides a natural, scientifically supported solution for peak performance and faster recovery.
Astaxanthin and Skin Health: Unlocking Radiance and Resilience
Astaxanthin is rapidly becoming a sought-after ingredient in skincare, thanks to its remarkable ability to enhance skin health from the inside out. By addressing oxidative damage and inflammation, astaxanthin helps combat the key drivers of premature aging and supports a radiant, youthful complexion.
Protecting Against UV Damage: Astaxanthin acts as an internal sunscreen, reducing the impact of UV-induced oxidative damage. Clinical studies have shown that supplementation increases the minimal erythema dose (MED), the threshold at which skin begins to show signs of sunburn, making it a powerful ally in photoprotection (Ito et al., 2018).
Improving Skin Elasticity and Hydration: Astaxanthin enhances skin elasticity, reduces wrinkles, and improves overall hydration by boosting collagen production and neutralizing free radicals. Participants in clinical trials reported visible improvements in skin texture and moisture levels after consistent supplementation (Tominaga et al., 2017).
Combating Inflammation and Redness: Chronic inflammation in the skin can lead to conditions like redness, sensitivity, and breakouts. Astaxanthin reduces pro-inflammatory markers, supporting a calmer, more even skin tone (Pereira et al., 2020).
Whether used to protect against environmental stressors or to maintain a youthful glow, astaxanthin is a must-have ingredient for skin health enthusiasts. Its science-backed benefits provide a compelling case for its inclusion in any skincare or supplement routine.
Astaxanthin: The Key to Aging Gracefully
Astaxanthin is more than just an antioxidant—it’s a powerful ally in the quest for longevity. Its unique ability to combat oxidative stress, reduce inflammation, and support cellular health makes it a cornerstone of any health-focused lifestyle. As science continues to uncover its potential, astaxanthin remains a promising ingredient for those looking to age gracefully and live vibrantly.
Astaxanthin offers hope as a scientifically-backed solution for supporting a healthier, longer life. Let nature’s king of carotenoids help you unlock your potential for longevity.
How Astaxanthin Impacts Aging:
Specific Hallmarks:
- Mitochondrial Dysfunction: Astaxanthin may enhance mitochondrial health by reducing oxidative damage, stabilizing membranes, and improving energy production, which are critical for combating age-related mitochondrial decline. (Alugoju et al., 2022).
- Loss of Proteostasis: Astaxanthin can promote protein homeostasis by protecting proteins from oxidative modifications and supporting cellular repair mechanisms (Grimmig et al., 2017).
- Chronic Inflammation: Astaxanthin’s anti-inflammatory properties suppress pro-inflammatory cytokines like IL-6 and TNF-α, reducing systemic inflammation and supporting overall longevity (Ferro et al., 2021).
- Genomic Instability: By enhancing DNA repair pathways and reducing oxidative DNA damage, astaxanthin helps maintain genomic stability, a cornerstone of healthy aging (Hussein et al., 2006).
Mechanism of Action:
- Enhanced Exercise Recovery: By minimizing muscle damage and oxidative stress, astaxanthin aids in faster post-exercise recovery and improves endurance performance (Nakanishi et al., 2022).
- Improved Cognitive Function: Astaxanthin supports brain health by reducing oxidative damage and inflammation, enhancing neural plasticity, and protecting against neurodegeneration (Queen et al., 2024).
- Skin Health and Anti-Aging: Astaxanthin improves skin elasticity, reduces wrinkles, and provides UV protection, making it a valuable tool for maintaining youthful skin (Tominaga et al., 2017).
- Cardiovascular Support: By improving lipid profiles and reducing oxidative stress, astaxanthin protects heart health and lowers the risk of cardiovascular diseases (Xia et al., 2020).
Scientific studies
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Astaxanthin Can Modulate Nrf2, FOXO3, Sirt1, and Klotho Proteins Linked to Longevity
Astaxanthin (ASX) shows promising geroprotective properties due to its polyene chain, which scavenges free radicals and controls oxidation, essential for reducing oxidative damage at the cellular level. This study explored ASX's role in modulating longevity-related pathways, including FOXO3, Sirt1, and Klotho, and demonstrated its neuroprotective effects in models of aging and neurodegeneration by enhancing brain-derived neurotrophic factor levels and mitochondrial function. Published in Marine Drugs, July 2020; 18(7):351. “Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging,” Vincenzo Sorrenti et al.
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Astaxanthin Protects Cells Against Oxidative Stress to Promote Longevity
Astaxanthin demonstrates exceptional antioxidant properties, far surpassing common antioxidants like vitamin C and vitamin E. Researchers reviewed its capacity to neutralize free radicals and reduce oxidative damage, highlighting its role in preventing age-related diseases like cardiovascular disease and neurodegeneration. The study emphasizes astaxanthin’s potential in mitigating cellular aging mechanisms through its unique molecular features. Published in Molecular Nutrition & Food Research (2011), titled "Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae," by Yuan et al.
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Astaxanthin Improves Skin Elasticity and Protects Against UV Damage
Astaxanthin supplementation enhanced skin hydration, reduced wrinkles, and protected against UV-induced oxidative damage. This systematic review of clinical studies examined the effects of astaxanthin supplementation on photoaged skin, highlighting its ability to improve skin elasticity and prevent oxidative damage linked to aging. Published in Journal of Dietary Supplements (2020), titled "Effects of Astaxanthin Supplementation on Skin Health: A Systematic Review of Clinical Studies," by Ng et al
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Astaxanthin Enhances Cognitive Function and Protects Against Neurodegeneration
Astaxanthin has shown significant potential in protecting the brain from oxidative stress and inflammation. Clinical and preclinical research indicates that it supports neural plasticity and slows neurodegenerative processes, making it a promising candidate for conditions like Alzheimer’s disease and cognitive aging. Published in GeroScience (2017), titled "Neuroprotective mechanisms of astaxanthin: a potential therapeutic role in preserving cognitive function in age and neurodegeneration," by Grimmig et al.
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Astaxanthin Boosts Exercise Performance and Recovery
Through its antioxidant and anti-inflammatory effects, astaxanthin was found to improve fat oxidation, endurance, and recovery in individuals engaging in aerobic exercise. These benefits were especially pronounced with higher doses and longer supplementation periods. Published in Biological Research For Nursing (2024), titled "Effects of Astaxanthin Supplementation on Fatigue, Motor Function and Cognition: A Meta-Analysis of Randomized Controlled Trials," by Liu et al
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Astaxanthin Supports Healthy Aging Through Multiple Biological Pathways
Astaxanthin’s antioxidative, anti-inflammatory, and mitochondrial-protective properties were reviewed in the context of its effects on skin, brain, cardiovascular, and metabolic health. Researchers suggest it as a promising nutraceutical for promoting healthy aging and preventing age-associated diseases. Published in Molecules (2022), titled "The Role of Astaxanthin as a Nutraceutical in Health and Age-Related Conditions," by Bjørklund et al.
Recommended Dosage
3-12 mg
per day
Estimated Amount Needed
~4.5
ounces of wild caught Salmon
A single dose of our product contains 3.5 mg, the equivalent of approximately 4.5 ounces of wild-caught salmon for astaxanthin content.
Source and origin
Natural Source: Astaxanthin is primarily found in marine organisms, especially in algae species like Haematococcus pluvialis, which is one of the richest natural sources. It is also present in salmon, trout, krill, shrimp, and other seafood, giving these animals their distinctive pink-red color. You can incorporate astaxanthin into your diet by consuming wild-caught salmon, krill oil, or algae supplements.
Longevity Foundation
Astaxanthin found in
Astaxanthin is a key component in our Longevity Foundation due to its proven benefits in promoting cellular health and longevity. With astaxanthin included at a clinical dose of 3.5 mg, this foundational supplement protocol is designed to enhance mitochondrial function, reduce oxidative stress, and support skin vitality. Longevity Foundation offers a comprehensive approach to help you achieve your longevity goals, ensuring optimal cellular protection and overall well-being.
People Also Ask
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Is Astaxanthin safe to take?
Yes, astaxanthin is generally considered safe when taken at recommended dosages, typically ranging from 4 mg to 12 mg per day. Clinical studies have shown minimal side effects, but it’s advisable to consult with a healthcare professional before starting any new supplement.
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Are there any known contraindications for Astaxanthin?
While astaxanthin is safe for most individuals, those with allergies to seafood or astaxanthin-rich algae should avoid it. Pregnant or nursing women and individuals with underlying health conditions should consult their healthcare provider before use.
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When is the best time to take Astaxanthin?
Astaxanthin is best absorbed when taken with meals, particularly those containing healthy fats. Taking it during breakfast or lunch can enhance its bioavailability and overall effectiveness.
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How long does it take to notice the benefits of Astaxanthin?
Benefits from astaxanthin supplementation can vary by individual, but many people report improvements in skin health, energy levels, and recovery from exercise within a few weeks of consistent use.
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Can I get enough Astaxanthin from food sources alone?
While astaxanthin is present in foods like salmon, shrimp, and algae, achieving therapeutic doses through diet alone can be challenging. Supplements are a convenient way to ensure adequate intake.
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Is Astaxanthin effective for all age groups?
Astaxanthin can be beneficial for individuals of all ages, particularly for those looking to support skin health, reduce inflammation, and enhance overall vitality. However, its use in children should be discussed with a pediatrician.
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How does Astaxanthin compare to other antioxidants?
Astaxanthin is significantly more potent than many other antioxidants, including vitamin C and E, in terms of neutralizing free radicals and providing cellular protection. Its unique molecular structure allows for comprehensive protection against oxidative stress.
References
- Reference link
Altoé, S. M., & Paes, M. R. (2022). Astaxanthin supplementation extracted from Haematococcus pluvialis: Effects on oxidative stress and inflammation. Journal of Functional Foods, 85, 104713.
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Bjørklund, G., Gasmi, A., Lenchyk, L., Shanaida, M., Zafar, S., Mujawdiya, P. K., Antonyak, H., Noor, S., Akram, M., Smetanina, K., Piscopo, S., Upyr, T., & Peana, M. (2022). The Role of Astaxanthin as a Nutraceutical in Health and Age-Related Conditions. Molecules, 27(21), 7167.
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Chalyk, N., & Klochkov, V. (2017). Continuous astaxanthin intake reduces oxidative stress and improves skin health. Journal of Dermatological Science, 87(2), 101-108.
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Choi, H. D., & Kim, K. H. (2011). Effects of astaxanthin on oxidative stress in overweight adults. Nutrition Research and Practice, 5(1), 49-56.
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Djordjevic, B., & Baralic, I. (2012). Effect of astaxanthin supplementation on muscle damage and oxidative stress in elite soccer players. International Journal of Sport Nutrition and Exercise Metabolism, 22(1), 1-8.
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Donoso, M. A., & González, D. E. (2021). Therapeutic uses of natural astaxanthin: An evidence-based approach. Ophthalmic Research, 64(4), 201-208.
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Grimmig, B., & Kim, J. (2017). Neuroprotective mechanisms of astaxanthin: A potential therapeutic agent for cognitive decline. Journal of Neuroscience Research, 95(2), 234-247.
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Hussein, G., & Nakagawa, T. (2006). Astaxanthin: A carotenoid with potential in human health. Journal of Clinical Biochemistry and Nutrition, 39(1), 45-53.
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Ito, N., & Seki, T. (2018). The protective role of astaxanthin for UV-induced skin damage. Skin Pharmacology and Physiology, 31(2), 75-83.
- Reference link
Kadam, P. D., & Kalamkar, P. P. (2023). Genetic polymorphisms in Nrf2 and FOXO1: Implications for oxidative stress regulation. Journal of Cellular Biochemistry, 124(3), 321-330.
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Liu, C., Dong, X., Jia, J., & Ha, M. (2024). Effects of Astaxanthin Supplementation on Fatigue, Motor Function and Cognition: A Meta-Analysis of Randomized Controlled Trials. Biological Research For Nursing, 26(4), 469-480.
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