Advanced Sleep Repair  - Jung+ Longevity
Advanced Sleep Repair
Advanced Sleep Repair
Advanced Sleep Repair
Advanced Sleep Repair
Advanced Sleep Repair
Advanced Sleep Repair
Advanced Sleep Repair
Advanced Sleep Repair
Advanced Sleep Repair
Advanced Sleep Repair  - Jung+ Longevity
Advanced Sleep Repair
Advanced Sleep Repair
Advanced Sleep Repair
Advanced Sleep Repair
Advanced Sleep Repair
Advanced Sleep Repair
Advanced Sleep Repair
Advanced Sleep Repair
Advanced Sleep Repair
SLEEP OPTIMIZATION PROTOCOL

Advanced Sleep Repair

4.9/5
| 1155+ Verified Reviews
$62per month

All-in-one sleep supplement for deeper rest and faster recovery to wake up refreshed. Clinically studied ingredients enhance natural melatonin production, accelerate tissue repair, and activate key longevity pathways—in a non-habit-forming formula.

  • Subscribe & Save

    Save & get free metal storage canisters

  • 90-Day Guarantee

    Buy risk-free

  • Cancel anytime

    Cancel whenever you need

Product description

Advanced Sleep Repair is a breakthrough sleep protocol scientifically formulated to maximize your body's overnight repair and rejuvenation. Its non-sedative, non-melatonin blend naturally enhances deep, restorative sleep—so you wake refreshed, mentally sharp, and physically recharged. Powered by precision ingredients that synergistically support cellular renewal and metabolic health, it's your nightly solution for better sleep and healthier aging.

  • Non-melatonin: Supports your body's own melatonin and natural circadian rhythms
  • Non-habit-forming: Promotes consistent, high-quality sleep without dependency
  • Balanced neurotransmitters: Enhances deep sleep for optimal mind and stress recovery
  • Muscle & skin rejuvenation: Accelerates overnight physical repair and growth
  • Convenient & delicious: Just one soothing scoop before bed (lemon chamomile flavor)

Ingredient list

Magnesium (as magnesium amino acid chelate complex) 400 mg
Vitamin B6 (as pyridoxal-5-phosphate) 15 mg
Zinc (as zinc bisglycinate chelate) 30 mg
Glycine 2500 mg
Taurine 1000 mg
GABA (gamma-aminobutyric acid) 750 mg
FruitSOURCE® tart cherry fruit 500 mg
L-Theanine 400 mg
L-Tryptophan 150 mg

Suggested use

How to use

Mix one scoop with one cup (8fl oz) water and drink before bedtime. Avoid eating meals 2 hours before bed for the best results.

Behavioral protocol

Maintain a consistent sleep schedule, limit screen exposure before bed, and avoid stimulants or work late at night. If nighttime trips to the bathroom are a concern, mix with less water to minimize disruptions while still reaping the full benefits.

Stay motivated with Jung+

More than just a supplement, your purchase unlocks personalized sleep optimization guidance, delivered straight to your inbox. Discover science-backed sleep tips, and stay accountable with cutting edge sleep and circadian research. Join today to elevate your longevity journey and achieve your sleep optimization goals with confidence.

Subscribe for VIP Benefits

One-Time Purchase

Buy on your terms. Each one-time purchase includes a one-month supply in a convenient, resealable pouch.

Subscribe to unlock VIP benefits

Join our subscription program and get more than just discounts—gain access to expert guidance, VIP perks, and science-backed longevity support. Plus, your welcome kit includes a free, 100% metal, recyclable storage canister to keep your monthly refills fresh and protected.

  • Personalized coaching & expert insights delivered straight to your inbox
  • Up to 25% off subscriptions with flexible delivery every 1, 6, or 12 months—cancel anytime
  • Exclusive white-glove support for personalized longevity guidance
  • Always up-to-date formulas, tracking the latest longevity breakthroughs
  • Priority access to new products, VIP discounts, & special perks

90-Day Satisfaction Guarantee

We believe in our products, so first-time subscribers can try Jung+ for 90 days with confidence.

If it’s not for you, we’ll refund your first month—no returns necessary.

  • ✅ Exclusive to first-time subscribers.
  • ✅ Try it for 90 days—if you’re not satisfied, get a refund.
  • ✅ No need to ship anything back.
  • ✅ To keep the process hassle-free and return-free, a small 15% processing fee applies.

    See Full Guarantee Policy →

Boost your routine
Advanced Sleep Repair
Ingredients
Vitamin B6 (as pyridoxal-5-phosphate)
15 mg
Magnesium (as magnesium amino acid chelate complex)
400 mg
Zinc (as zinc bisglycinate chelate)
30 mg
Glycine
2,500 mg
Taurine
1,000 mg
GABA (gamma-aminobutyric acid)
750 mg
FruitSOURCE® tart cherry fruit
500 mg
L-Theanine
400 mg
L-Tryptophan
150 mg

As seen in

Marquee image
Marquee image
Marquee image
Marquee image
Marquee image
Marquee image
Marquee image
Marquee image
Marquee image
Marquee image
Marquee image
Marquee image
Marquee image

Sleep Deeper, Live Younger.

The advanced sleep formula clinically designed to rejuvenate your body, sharpen your mind, and promote healthy aging—night after night.

Your complete sleep optimization protocol

Discover the unique benefits that set us apart.

Engineered for Deeper, Smarter Sleep

Optimizes sleep biology and overnight recovery naturally.

Unlike traditional sleep sedatives that leave you feeling groggy, Advanced Sleep Repair is precisely designed to improve sleep efficiency, depth, and quality naturally (2,3), by improving sleep biology over time. Its advanced formulation utilizes a full stack of key ingredients to enhance your body's innate overnight regeneration processes—so you wake refreshed, energized, and mentally sharp, fully ready to perform at your best. Experience true restorative sleep and rejuvenation every night, without sedatives or grogginess (4, 5).

All references

Overnight Muscle & Skin Repair

Recover faster, build lean muscle, and rejuvenate your skin while you sleep.

Your body rebuilds itself at night—repairing muscles, strengthening joints, and regenerating youthful skin. Advanced Sleep Repair actively supports and accelerates this overnight recovery, helping you bounce back faster and stronger, whether from intense workouts or daily wear and tear. Glycine and magnesium provide crucial building blocks for collagen synthesis, essential for muscle growth, healthy joints, and youthful skin (41, 45-47). Taurine and sour cherry extract further speed muscle recovery, ease inflammation, and reduce post-exercise soreness—trusted by elite athletes to boost performance and recovery naturally (48-50). Finally, zinc enhances protein synthesis and immune function, ensuring comprehensive tissue regeneration night after night (51).

All references

Sharper Mind, Healthier Brain

Enhances memory, mental clarity, and brain health while you sleep.

Your brain uses sleep as a critical time to consolidate memories, sharpen attention, and regenerate neurons. Advanced Sleep Repair enhances these processes naturally, using glycine and L-theanine to support memory and cognitive clarity (28-32). Magnesium and vitamin B6 further balance neurotransmitters, essential for protecting your brain against stress and cognitive decline (33,34). By optimizing your overnight brain health, you'll awaken with improved mental sharpness, better mood, and enhanced resilience against cognitive aging.

All references

Supports Natural Melatonin for Circadian Balance

Restores your body's internal clock for consistent, rejuvenating sleep.

Melatonin—the hormone that regulates your sleep-wake cycle—declines as you age, causing disrupted sleep and accelerating signs of aging (6-8). Unlike external melatonin supplements that give some people ‘melatonin hangovers’, Advanced Sleep Repair supports your body's own melatonin production using a precise blend of L-tryptophan, vitamin B6, taurine, and tart cherry extract. These ingredients work synergistically to naturally boost melatonin levels, helping you consistently fall asleep faster, stay asleep longer, and wake up feeling refreshed, without the risk of grogginess (12-16).

All references

Balanced Neurotransmitters For Stress-Free Sleep

Supports a calm mind and restful sleep by balancing neurotransmitters.

Advanced Sleep Repair supports balanced neurotransmitters to help calm your mind, ease anxiety, and promote deeper sleep. Ingredients like L-theanine and GABA work together to quiet mental chatter and soothe restlessness (55, 56, 60, 76). Vitamin B6 enhances serotonin and GABA production, boosting mood and relaxation (64, 65). Glycine and magnesium further reduce muscle tension, supporting a relaxed body and uninterrupted sleep (33, 66, 67). Taurine complements this calming effect by gently moderating brain activity, easing stress-induced tension (68, 69). Wake refreshed, clear-minded, and stress-free—without dependency.

All references

Cellular Rejuvenation: DNA Repair & Oxidative Protection

Enhance overnight repair, defending against cellular aging.

Advanced Sleep Repair enhances your body’s natural overnight repair processes, actively defending against DNA damage and harmful oxidative stress—key drivers of aging (17, 22). Magnesium and zinc provide essential support for nightly DNA repair, acting as cofactors for enzymes that fix accumulated cellular damage (18, 19). Glycine promotes overnight synthesis of glutathione, the body's master antioxidant, crucial for neutralizing damaging free radicals during sleep (23). Taurine further neutralizes oxidative stress by scavenging free radicals, while sour cherry extract adds antioxidant power to protect your cells from age-related damage (24-27). Wake restored, resilient, and rejuvenated from the inside out.

All references

Restful Sleep, Without Dependency

Enjoy better sleep every night—naturally, safely, and without sedatives.

Advanced Sleep Repair gently improves your natural sleep patterns without the risks of sedative dependence or morning grogginess (52, 53). Unlike chemical sleep aids that mask underlying issues, our formula safely enhances your body's innate ability to fall asleep naturally. With consistent use alongside healthy sleep habits, it promotes lasting improvements in sleep quality, helping you establish sustainable, restorative sleep—so you wake refreshed and energized every day (54).

All references

How to use

Mix one scoop with one cup (8fl oz) water and drink before bedtime, daily. Avoid eating meals 2 hours before bed for best results. For enhanced synergistic effects, combine with Longevity Foundation AM/PM.

+ behavioral protocol

Maintain a consistent sleep schedule and establish a calming bedtime routine. Reduce exposure to electronics prior to sleeping. Avoid stimulants and heavy meals before bedtime. Incorporate regular exercise into your routine while avoiding activity near bedtime. Keep daytime napping to a minimum. 

+ WARNING

Not recommended for children or if pregnant or nursing. Consult your healthcare provider before use if you have a medical condition or take medication.

9 research-backed ingredients

Advanced Sleep Repair is made with powerful ingredients that have been shown in research studies to support sleep and improve healthspan.

Magnesium (amino acid chelate complex)

400 mg

Magnesium naturally calms your nervous system, reducing stress and preparing your body for restful sleep by regulating key neurotransmitters like GABA and melatonin (62, 63, 80). Studies show it improves sleep efficiency, shortens the time it takes to fall asleep, and reduces nighttime restlessness (62, 63, 80). Additionally, magnesium supports genomic stability, cardiovascular health, balanced blood sugar, and healthy inflammation responses—further optimizing your overall longevity (43, 80).
All references

L-theanine

400 mg

L-theanine, an amino acid naturally found in tea, enhances relaxation by increasing calming alpha brain waves, helping you unwind and fall asleep faster (55, 56). It improves deep sleep quality, reduces nighttime awakenings, and supports mental clarity and mood (55, 56, 30). It also offers powerful longevity benefits by activating protective antioxidant pathways, helping defend your brain from age-related stress (74). Each serving provides the relaxing benefits of about 20 cups of green tea—in just one scoop.
All references

Tart Cherry Extract

500 mg

Sour cherry extract contains natural phyto-melatonin, shown to support healthier sleep cycles more effectively than synthetic melatonin supplements (14, 86). This potent natural ingredient helps you fall asleep faster, improves overall sleep quality, and reduces symptoms of insomnia and jet lag (14, 86). Additionally, its powerful antioxidants soothe muscle inflammation, aiding physical recovery—making it a favorite among elite athletes seeking faster recovery after intense exercise (87).
All references

Glycine

2,500 mg

Glycine improves your sleep by reducing the time it takes to fall asleep and increasing sleep efficiency (77, 78). It stimulates autophagy—your body’s natural "clean-up" process—by mimicking the anti-aging effects of methionine restriction (37, 41). Glycine also supports overnight production of glutathione, your body’s master antioxidant, combating oxidative stress and cellular aging (23). Additionally, glycine is a crucial building block for collagen synthesis, promoting youthful skin (45, 46), and actively aids tissue and muscle repair overnight (41). It helps regulate the sleep-wake cycle and has been shown to extend lifespan in various organisms, including multiple mammalian models.
All references

GABA

750 mg

GABA is your brain's natural calming neurotransmitter, easing anxiety and stress by reducing excess brain activity (60, 76). Supplementation can help you fall asleep faster, stay asleep longer, and improve overall sleep quality—without sedation (60, 76). By naturally quieting your mind, GABA supports deeper sleep, leaving you refreshed and mentally clear.
All references

Vitamin B6 (pyridoxal-5-phosphate)

15 mg

Vitamin B6, provided in its bioactive form (pyridoxal-5-phosphate), helps your body naturally produce serotonin and melatonin—crucial hormones for restful sleep and mood stability (12). Paired with magnesium, it becomes even more effective—activating neurotransmitter pathways to enhance sleep quality, relaxation, and overall nighttime recovery (42). To match the potency in Advanced Sleep Repair, you'd need to consume around 1.7 kg of canned tuna, demonstrating the supplement’s concentrated strength in just one scoop.
All references

Taurine

1,000 mg

Taurine promotes relaxation and calmness, naturally supporting restful, rejuvenating sleep (72). Its powerful antioxidant effects protect your cells from oxidative stress, supporting healthy aging and overall vitality (24, 83). Studies show taurine supplementation significantly extended lifespan by 10-12% in middle-aged mice, improving the health and function of critical organs including the brain, muscles, bones, pancreas, gut, and immune system (21). Each serving of Advanced Sleep Repair delivers as much taurine as you'd find in 4.4 pounds (2 kg) of chicken breast, providing targeted longevity support in every scoop.
All references

L-Tryptophan

150 mg

L-tryptophan is an essential amino acid your body uses to produce serotonin and melatonin, crucial neurotransmitters for balanced mood, relaxation, and restful sleep (84, 85). Studies demonstrate that L-tryptophan supplementation reduces the time it takes to fall asleep and improves overall sleep quality naturally (84, 85). It’s the same calming nutrient famously associated with turkey and pumpkin seeds—helping you ease into deep, rejuvenating sleep each night.
All references

Zinc

30 mg

Zinc is an essential mineral involved in producing key sleep-regulating neurotransmitters like serotonin and melatonin (88, 89). Supplementing with zinc has been shown to improve sleep quality, minimize nighttime awakenings, and help you achieve deeper, more restful sleep (88, 89). By addressing common deficiencies, zinc promotes consistent sleep patterns and more efficient nightly recovery.
All references

Your 12 month sleep optimization journey

2 weeks

Enhanced Sleep Patterns

Some users may experience falling asleep faster, deeper sleep cycles, and waking up feeling more rested.

6 weeks

Improved Recovery and Energy

Users may start to notice better overnight recovery, increased energy levels during the day, and reduced stress levels for improved focus.

3 months

Cognitive and Physical Boost

Many report sharper mental clarity, better emotional balance, and noticeable improvements in muscle and tissue repair from optimized sleep quality.

6 months

Enhanced Longevity Markers

Consistent use may lead to sustained improvements in metabolic health, reduced oxidative stress, and visible signs of rejuvenation, such as healthier skin and overall vitality.

12 months

Long Term Sleep Transformation

Users often experience consistently high-quality sleep, enhanced resilience to stress, and a foundation for long-term health and longevity through optimized cellular repair and recovery.

How can sleep impact longevity?

Learn more

Sleep is the single most effective thing we can do to reset our brain and body health each day: Mother Nature's best effort yet at contra-death

Matthew Walker, Author of Why We Sleep: Unlocking the Power of Sleep and Dreams

Founded in Oxford - we’ve done our homework

At Jung+, we're on a crusade to liberate human longevity, translating the latest scientific advancements in aging research into products and technologies that can slow aging and extend healthy lifespan

Our scientists

GMP certified

Manufactured in facilities that follow Good Manufacturing Practices (GMP), ensuring the highest quality and purity.

Scientist Approved

Formulated by experts and rigorously evaluated by scientists to ensure effectiveness and safety.

Clinical-Grade Dosage

Contains the precise dosages used in clinical studies, ensuring you receive the optimal amount for maximum benefit.

Made in the USA

Proudly produced in the USA, ensuring adherence to the highest standards of quality and safety.

Meet our JUNG+ community

“I've researched it all: Jung delivers the best”

“Feeling younger, stronger, and more vibrant every single day”

“Longevity never felt so effortless— I'm obsessed with these products!”

FAQ’s

  • What is Advanced Sleep Repair?

    Advanced Sleep Repair is a carefully formulated dietary supplement that supports healthy sleep patterns, promotes a restful night's sleep, and helps enhance the age-rejuvenation properties of sleep. In essence, it aims to support deep sleep as well as amplifying regenerative mechanisms that occur during sleep.

  • How does Advanced Sleep Repair work?

    Advanced Sleep Repair combines key ingredients such as L-theanine, GABA, glycine, magnesium, vitamin B6, L-tryptophan, sour cherry extract, and zinc to promote relaxation, support neurotransmitter balance, regulate body temperature, and provide natural melatonin. It also provides ingredients that relate to essential overnight repair and renewal mechanisms. These components work synergistically to help calm the mind, ease stress, optimize sleep quality, and enhance the longevity therapeutic properties of sleep.

  • How should I take Advanced Sleep Repair?

    Mix one scoop with one cup (8fl oz) water and drink before bedtime. It's recommended to avoid eating meals 2 hours before bed for the best results. Take Advanced Sleep Repair daily. For enhanced synergistic effects, combine with Longevity Foundation AM/PM.

  • Is Advanced Sleep Repair suitable for everyone?

    Advanced Sleep Repair is generally well-tolerated, but individual responses may vary. However, its not recommended for children, or for pregnant or nursing women. It is important to consult with your healthcare professional before starting any new supplement regimen, especially if you have any underlying medical conditions, are taking medications, are pregnant, or are breastfeeding. Of course, this product is not suitable for individuals who are allergic or hypersensitive to any component of the formula.

  • Can I become dependent on Advanced Sleep Repair for sleep?

    Advanced Sleep Repair is not habit-forming or addictive when used as directed. It is intended to support healthy sleep patterns and promote a restful night's sleep without causing dependency. Following the recommended dosage and consult with your healthcare professional is always advisable.

  • How long does it take for Advanced Sleep Repair to work?

    The effects of Advanced Sleep Repair may vary among individuals. While some individuals may experience noticeable improvements in sleep quality and relaxation on the first night, others may require more time to observe the full benefits. Consistency in use and adherence to healthy sleep habits are key to achieving optimal results.

  • How can I enhance the effectiveness of Advanced Sleep Repair?

    Maintain a consistent sleep schedule and establish a calming bedtime routine. Reduce exposure to electronics prior to sleeping. Avoid stimulants and heavy meals before bedtime. Incorporate regular exercise into your routine, but avoid strenuous activity near bedtime. Manage stress with relaxation techniques. Keep daytime napping to a minimum. Refrain from consuming alcohol and nicotine before bed.

  • I experience excessive overnight urination, and I'm concerned that drinking a cup of this product will disturb my sleep. What should I do?

    We understand your concern about overnight urination, especially when it comes to drinking fluids before bedtime. Our product is designed to provide therapeutic benefits, but we recommend adapting its consumption to suit your individual needs and comfort.

    One effective approach is to consume the drink 30 to 60 minutes before your bedtime. This timing allows your body enough time to process the liquid and significantly reduces the likelihood of nighttime disruptions. Additionally, you might consider limiting other liquids before bed to make up for this, or starting with a smaller amount of the drink to assess your body’s response and gradually increase to the recommended serving size as you become more comfortable with its effects.

    Remember, it’s important to maintain a balance between getting the benefits of our product and ensuring a good night's sleep. Adjusting the timing of consumption could be a key factor in achieving this balance. If you continue to experience concerns, we recommend consulting with a healthcare professional to discuss your specific situation and needs.

Developed by experts

Dr. Sagner is a world leading human performance specialist, sports and preventive medicine, and was the medical director at Europe’s first University medical center section for preventive medicine and lifestyle medicine. Dr Sagner is a member of the European Union Platform for Action on Diet, Physical Activity and Health and a partner of the European Innovation Partnership on Active and Healthy Aging.

Dr. Michael Sagner, MD

DIRECTOR, EUROPEAN SOCIETY OF PREVENTIVE MEDICINE
Francois-Xavier Pellay, PhD, known as the 'Longevity Molecule Hunter', is a world leading scientist and entrepreneur in the longevity industry. Pellay is a multidisciplinary scientist with a background which includes a Master's degree in Biochemistry, a Master's degree in Organic Chemistry, a Ph.D. in Bioinformatics and years of expertise in Microbiology, Molecular Biology, Cellular Biology and Biology of Aging.

Francois-Xavier Pellay, PhD

PROFESSOR | SCIENTIST | LONGEVITY MOLECULE HUNTER | FOUNDER, BIMINI BIOTECH
Dr. Fady Hannah-Shmouni, MD FRCPC, is a physician-investor at the forefront of endocrinology, genomics, and healthspan medicine. As a distinguished Professor at the University of British Columbia, he passionately empowers individuals by facilitating access to groundbreaking technologies in precision medicine, including artificial intelligence and genomic advancements.

Dr. Fady Hannah-Shmouni

LONGEVITY PHYSICIAN | PROFESSOR | YALE SCHOOL OF MEDICINE | NIH | UNIVERSITY OF BRITISH COLUMBIA
Dr. Avi Roy is an accomplished biomedical scientist, mentor, and entrepreneur with a deep-rooted passion for advancing the field of longevity. His academic journey culminated in a PhD from the University of Oxford. With over 15 years of dedicated research and development in the longevity sector, Dr. Roy has established himself as a a leading figure in this dynamic and ever-evolving field. As a mentor and investor in health-tech startups, he continues to inspire and guide the next generation of scientists and entrepreneurs.

Avi Roy

BIOMEDICAL SCIENTIST | INVENTOR | UNIVERSITY OF OXFORD | FOUNDER, UDA

Scientific studies

  • Glycine improved subjective sleep quality and sleep efficacy.

    The effects of taking glycine (3 g) before bedtime were examined in a study on individuals with unsatisfactory sleep. The results showed that glycine improved subjective sleep quality and efficacy (sleep time divided by time spent in bed). It also reduced the time to fall asleep and reach slow-wave sleep without affecting the overall sleep architecture. Additionally, glycine reduced daytime sleepiness and enhanced performance in memory recognition tasks. These findings suggest that when ingested before bedtime, glycine can improve subjective and objective measures of sleep quality in a manner different from traditional hypnotic drugs like benzodiazepines (90).

  • Glycine helps maintain healthy cognition and brain aging

    The effects of Bioglycin, a form of glycine that interacts with the N-methyl D-aspartate receptor complex, were studied in young and middle-aged individuals to assess attention, memory, and mood. In a double-blind, randomized, crossover study, healthy students (mean age, 20.7 years) and middle-aged men (mean age, 58.9 years) were tested. The middle-aged group showed poorer verbal episodic memory, attention, and subjective responses compared to the young group. Bioglycin improved episodic memory in both groups and enhanced sustained attention in middle-aged men. Unlike other cognitive enhancers, Bioglycin lacked stimulant properties, had no significant effects on mood, and primarily improved memory rather than attention. It may be beneficial for situations requiring high retrieval of information or when performance is affected by factors like jet lag, shift work, or disrupted sleep (29).

  • Glycine and Aging: Evidence and Mechanisms

    The simple amino acid glycine extends lifespan in worms, mice, and rats. Glycine also improves aspects of health in mammalian models of age-related disease. Glycine is the acceptor for GNMT, an enzyme responsible for methionine clearance. GNMT also converts glycine to sarcosine, an autophagy-inducing metabolite. Glycine may prolong life by inducing autophagy and mimicking methionine restriction.

  • L-theanine in green tea as potential shield from dementia and stress-induced aging.

    Slowing brain aging is crucial for preventing dementia, as aging is the primary risk factor. Green tea catechins (GTCs) have potent antioxidant activity and can reduce oxidative damage, brain atrophy, and cognitive decline in aged mice. Ingesting GTCs or drinking green tea at a middle-aged stage can suppress age-related cognitive decline. Chronic stress accelerates brain aging, but L-theanine, an amino acid in green tea, can mitigate stress-induced aging. Regular consumption of green tea is beneficial in slowing brain aging, and theanine-rich green tea or low-caffeine green tea may help suppress stress and stress-induced aging (93).

  • L-Theanine protects against DNA damage

    The study investigated the protective effect of L-theanine against irinotecan-induced DNA damage in mouse bone marrow cells. L-theanine, given at doses equivalent to 30 or 60 mg/kg for 12 days, showed no genotoxic or cytotoxic effects. Pretreatment with L-theanine reduced irinotecan-induced genomic damage in bone marrow cells in a dose-dependent manner. Irinotecan caused oxidative DNA stress, but L-theanine administration mitigated these effects by modulating cellular antioxidant levels. The findings suggest that L-theanine has a protective role in preventing irinotecan-induced DNA damage in mouse bone marrow cells (94).

  • GABA/L-theanine mixture has a positive synergistic effect on sleep quality and duration

    The GABA/L-theanine mixture decreased sleep latency and increased sleep duration compared to GABA or L-theanine alone. REM and NREM sleep were significantly increased with the combination, indicating improved sleep quality. The mixture restored normal sleep time and quality in an animal model of caffeine-induced awareness. The increased expression of GABA and the glutamate GluN1 receptor subunit suggests that the GABA/L-theanine combination has neuromodulatory effects on sleep behavior (61).

  • Magnesium crucial in maintaining genomic stability (a Hallmark of Aging).

    Magnesium is an essential element involved in various metabolic pathways and plays a crucial role in maintaining genomic stability. It is not genotoxic and helps stabilize DNA and chromatin structure. Magnesium serves as a cofactor in enzymatic systems responsible for DNA processing, ensuring high fidelity during DNA replication and facilitating DNA damage repair. Intracellular magnesium levels are tightly regulated and contribute to cell cycle control and apoptosis. Magnesium deficiency can affect membrane integrity, increase susceptibility to oxidative stress, and be linked to cardiovascular diseases and accelerated aging. The relationship between magnesium and tumor formation is complex, as it may have protective effects at early stages but promote tumor growth later on. Marginal magnesium deficiencies are common due to inadequate daily intake in many industrialized countries, falling below recommended dietary allowances (17).

  • Supplementation with magnesium reduces oxidative DNA damage

    This study aimed to assess the impact of four-week magnesium supplementation on DNA integrity in individuals with sedentary lifestyles and rugby players. Sedentary lifestyle is associated with increased risks of cardiovascular disease, obesity, and type 2 diabetes, while strenuous exercise can induce oxidative stress and DNA damage. Using the comet assay, the study found that rugby players had significantly higher levels of DNA damage in peripheral blood lymphocytes compared to sedentary students. However, magnesium supplementation reduced the number of cells with high DNA damage in both groups when exposed to H2O2, and in rugby players, it also reduced the number of cells with medium DNA damage. These findings suggest that four-week magnesium supplementation can protect DNA from oxidative damage in both sedentary individuals and rugby players (95).

  • Taurine deficiency as a driver of aging.

    Taurine, a semi-essential micronutrient abundant in humans and other eukaryotes, emerges as a potential influencer in the aging process. Research indicates that taurine levels in the blood decrease with age in various species, including mice, monkeys, and humans. Notably, administering taurine orally to middle-aged C57Bl/6J mice led to a visible extension in their median lifespan by 10 to 12% and an increase in life expectancy at 28 months by approximately 18 to 25%. This treatment also significantly enhanced their overall health, as evidenced by improved organ functionality. Similar benefits in health span were observed in monkeys. While taurine's impact was not significant in unicellular yeast, it did extend the lifespan of multicellular worms. The supplementation of taurine positively influenced several critical aspects of aging, such as reducing cellular aging, defending against deficiencies in telomerase, lessening mitochondrial dysfunction, curbing DNA damage, and diminishing inflammation. In humans, lower levels of taurine and related compounds correlate with various health problems, including obesity, hypertension, inflammation, and diabetes. Additionally, exercise was found to elevate levels of taurine metabolites, potentially linking physical activity's anti-aging benefits to taurine (21).

  • L-Tryptophan supplementation can help improve sleep quality.

    This study aimed to assess the effect of L-tryptophan (Trp) supplementation on sleep quality by analyzing existing research through a meta-analysis. Sleep disturbances have been linked to various health conditions, so understanding the impact of Trp on sleep is essential. A total of 18 articles were collected and analyzed for sleep outcomes such as total sleep time, sleep latency, wake after sleep onset and sleep efficiency. The results indicated that Trp supplementation can reduce wake-after-sleep onset (WASO). The analysis also revealed that a Trp dose of at least 1g was more effective in lowering WASO compared to a dose below 1g. However, Trp supplementation did not show significant effects on other sleep components. In conclusion, Trp supplementation, particularly at 1g or more doses, can help improve sleep quality (15).

  • Consuming a tart cherry juice concentrate improves sleep duration and quality.

    A study investigated the effects of tart cherry juice concentrate on urinary melatonin levels and sleep quality in healthy adults. Participants consumed either cherry juice or a placebo for 7 days. The cherry juice group showed increased melatonin levels and improved sleep duration and quality. These findings suggest that tart cherry juice concentrate may increase melatonin levels and enhance sleep in healthy individuals (14).

  • Glycine oral supplemenyation effectively decreases oxidative stress in individuals diagnosed with metabolic syndrome, by improving the systolic blood pressure.

    Abdominal fat and uncontrolled glucose metabolism contribute to oxidative stress and metabolic syndrome (MetS). This study examined the effects of glycine supplementation on antioxidant enzymes and lipid peroxidation in 60 MetS patients. Half of the participants received 15g/day of glycine for 3 months, while the other half received a placebo. Glycine supplementation led to a 25% decrease in lipid peroxidation and a 20% reduction in superoxide dismutase activity. Additionally, glycine-treated individuals experienced increased glucose-6-phosphate dehydrogenase activity and reduced systolic blood pressure. These findings highlight the role of glycine in balancing redox reactions and protecting against oxidative damage in MetS patients (23).

  • The consumption of L-theanine offers cognitive benefits.

    L-theanine was investigated for its positive impact on recognition memory in young rats. Following weaning, the rats were provided with water containing 0.3% L-theanine for three weeks. In the object recognition test, rats that received theanine maintained their memory after 48 hours, while the control group did not. Additionally, the levels of brain-derived neurotropic factor and nerve growth factor in the hippocampus were visibly higher in L-theanine-administered rats. These findings highlight the beneficial effects of L-theanine intake on recognition memory, suggesting its potential role in the development of hippocampal function after weaning (92).

All References

  1. Baugh A, Buhr RG, Quibrera P, Barjaktarevic I, Barr RG, Bowler R, et al. Risk of COPD exacerbation is increased by poor sleep quality and modified by social adversity. Sleep. 2022;45(8).
  2. Libman E, Fichten C, Creti L, Conrod K, Tran D-L, Grad R, et al. Refreshing sleep and sleep continuity determine perceived sleep quality. Sleep Disorders. 2016;2016.
  3. Reed DL, Sacco WP. Measuring sleep efficiency: what should the denominator be? Journal of clinical sleep medicine. 2016;12(2):263-6.
  4. Fuller PM, Gooley JJ, Saper CB. Neurobiology of the sleep-wake cycle: sleep architecture, circadian regulation, and regulatory feedback. Journal of biological rhythms. 2006;21(6):482-93.
  5. Cornwall W. Deep sleep. American Association for the Advancement of Science; 2015.
  6. Brzezinski A, Vangel MG, Wurtman RJ, Norrie G, Zhdanova I, Ben-Shushan A, et al. Effects of exogenous melatonin on sleep: a meta-analysis. Sleep medicine reviews. 2005;9(1):41-50.
  7. Zhdanova IV, Lynch HJ, Wurtman RJ. Melatonin: a sleep-promoting hormone. Sleep. 1997;20(10):899-907.
  8. Dawson D, Encel N. Melatonin and sleep in humans. Journal of pineal research. 1993;15(1):1-12.
  9. Ma L, Liu Q, Tian M, Tian X, Gao L. Mechanisms ​of melatonin in anti-aging and its regulation effects in radiation-induced premature senescence. Radiation Medicine and Protection. 2021;2(1):33-7.
  10. Anisimov VN, Popovich IG, Zabezhinski MA, Anisimov SV, Vesnushkin GM, Vinogradova IA. Melatonin as antioxidant, geroprotector and anticarcinogen. Biochim Biophys Acta. 2006;1757(5-6):573-89.
  11. Karasek M. Melatonin, human aging, and age-related diseases. Exp Gerontol. 2004;39(11-12):1723-9.
  12. Cellini B, Zelante T, Dindo M, Bellet MM, Renga G, Romani L, et al. Pyridoxal 5'-Phosphate-Dependent Enzymes at the Crossroads of Host-Microbe Tryptophan Metabolism. Int J Mol Sci. 2020;21(16).
  13. Lee BH, Hille B, Koh D-S. Serotonin modulates melatonin synthesis as an autocrine neurotransmitter in the pineal gland. Proceedings of the National Academy of Sciences. 2021;118(43):e2113852118.
  14. Howatson G, Bell PG, Tallent J, Middleton B, McHugh MP, Ellis J. Effect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep quality. European journal of nutrition. 2012;51(8):909-16.
  15. Sutanto CN, Loh WW, Kim JE. The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression. Nutr Rev. 2022;80(2):306-16.
  16. Wheler GHT, Weller JL, Klein DC. Taurine: Stimulation of pineal N-acetyltransferase activity and melatonin production via a beta-adrenergic mechanism. Brain Research. 1979;166(1):65-74.
  17. Hartwig A. Role of magnesium in genomic stability. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 2001;475(1-2):113-21.
  18. Fenech M. The role of nutrition in DNA replication, DNA damage prevention and DNA repair. Principles of nutrigenetics and nutrigenomics: Elsevier; 2020. p. 27-32.
  19. Kaźmierczak-Barańska J, Boguszewska K, Karwowski BT. Nutrition can help DNA repair in the case of aging. Nutrients. 2020;12(11):3364.
  20. Messina SA, Dawson R. Attenuation of Oxidative Damage to Dna by Tairome and Taurine Analogs. In: Della Corte L, Huxtable RJ, Sgaragli G, Tipton KF, editors. Taurine 4: Taurine and Excitable Tissues. Boston, MA: Springer US; 2002. p. 355-67.
  21. Singh P, Gollapalli K, Mangiola S, Schranner D, Yusuf MA, Chamoli M, et al. Taurine deficiency as a driver of aging. Science. 2023;380(6649):eabn9257.
  22. Sekhar RV, Patel SG, Guthikonda AP, Reid M, Balasubramanyam A, Taffet GE, et al. Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. Am J Clin Nutr. 2011;94(3):847-53.
  23. Díaz-Flores M, Cruz M, Duran-Reyes G, Munguia-Miranda C, Loza-Rodríguez H, Pulido-Casas E, et al. Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure. Canadian journal of physiology and pharmacology. 2013;91(10):855-60.
  24. Oliveira MW, Minotto JB, de Oliveira MR, Zanotto-Filho A, Behr GA, Rocha RF, et al. Scavenging and antioxidant potential of physiological taurine concentrations against different reactive oxygen/nitrogen species. Pharmacological reports : PR. 2010;62(1):185-93.
  25. Saraswati AAEW, Sunardi D, Lubis AMT, Heru F, Mudjihartini N. Taurine Intakes Increase Superoxide Dismutase Activity in Knee Osteoarthritis. IOP Conference Series: Earth and Environmental Science. 2019;217(1):012054.
  26. Blando F, Gerardi C, Nicoletti I. Sour Cherry (Prunus cerasus L) Anthocyanins as Ingredients for Functional Foods. Journal of biomedicine & biotechnology. 2004;2004(5):253-8.
  27. Damar İ, Ekşi A. Antioxidant capacity and anthocyanin profile of sour cherry (Prunus cerasus L.) juice. Food Chemistry. 2012;135(4):2910-4.
  28. Gusev EI, Skvortsova VI, Dambinova SA, Raevskiy KS, Alekseev AA, Bashkatova VG, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovascular diseases (Basel, Switzerland). 2000;10(1):49-60.
  29. File S, Fluck E, Fernandes C. Beneficial Effects of Glycine (Bioglycin) on Memory and Attention in Young and Middle-Aged Adults. Journal of clinical psychopharmacology. 2000;19:506-12.
  30. Kahathuduwa CN, Dassanayake TL, Amarakoon AMT, Weerasinghe VS. Acute effects of theanine, caffeine and theanine–caffeine combination on attention. Nutritional Neuroscience. 2017;20(6):369-77.
  31. Camfield DA, Stough C, Farrimond J, Scholey AB. Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysis. Nutr Rev. 2014;72(8):507-22.
  32. Takeda A, Sakamoto K, Tamano H, Fukura K, Inui N, Suh SW, et al. Facilitated neurogenesis in the developing hippocampus after intake of theanine, an amino acid in tea leaves, and object recognition memory. Cellular and molecular neurobiology. 2011;31(7):1079-88.
  33. Zhang Y, Chen C, Lu L, Knutson KL, Carnethon MR, Fly AD, et al. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study. Sleep. 2022;45(4).
  34. Olaso‐Gonzalez G, Inzitari M, Bellelli G, Morandi A, Barcons N, Viña J. Impact of supplementation with vitamins B6, B12, and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: a systematic review. IUBMB Life. 2022;74(1):74-84.
  35. Noah L, Dye L, Bois De Fer B, Mazur A, Pickering G, Pouteau E. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial. Stress and health : journal of the International Society for the Investigation of Stress. 2021;37(5):1000-9.
  36. Ford AH, Almeida OP. Effect of vitamin B supplementation on cognitive function in the elderly: a systematic review and meta-analysis. Drugs & aging. 2019;36:419-34.
  37. Gannon MC, Nuttall JA, Nuttall FQ. The metabolic response to ingested glycine. Am J Clin Nutr. 2002;76(6):1302-7.
  38. Bae M, Ahmed K, Yim JE. Beneficial Effects of Taurine on Metabolic Parameters in Animals and Humans. J Obes Metab Syndr. 2022;31(2):134-46.
  39. Ding Y, Svingen GF, Pedersen ER, Gregory JF, Ueland PM, Tell GS, et al. Plasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectoris. Journal of the American Heart Association. 2015;5(1).
  40. Alves A, Bassot A, Bulteau A-L, Pirola L, Morio B. Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases. Nutrients. 2019;11(6):1356.
  41. Johnson AA, Cuellar TL. Glycine and aging: Evidence and mechanisms. Ageing Research Reviews. 2023;87:101922.
  42. Rodríguez-Moran M, Guerrero-Romero F. Oral magnesium supplementation improves the metabolic profile of metabolically obese, normal-weight individuals: a randomized double-blind placebo-controlled trial. Archives of medical research. 2014;45(5):388-93.
  43. Barbagallo M, Dominguez LJ. Magnesium Role in Health and Longevity. In: Malavolta M, Mocchegiani E, editors. Trace Elements and Minerals in Health and Longevity. Cham: Springer International Publishing; 2018. p. 235-64.
  44. Parra M, Stahl S, Hellmann H. Vitamin B₆ and Its Role in Cell Metabolism and Physiology. Cells. 2018;7(7).
  45. de Paz-Lugo P, Lupiáñez JA, Meléndez-Hevia E. High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis. Amino Acids. 2018;50(10):1357-65.
  46. Kalhan SC, Gruca L, Marczewski S, Bennett C, Kummitha C. Whole body creatine and protein kinetics in healthy men and women: effects of creatine and amino acid supplementation. Amino Acids. 2016;48(3):677-87.
  47. Beckstrand RL, Pickens JS. Beneficial effects of magnesium supplementation. Journal of Evidence-Based Complementary & Alternative Medicine. 2011;16(3):181-9.
  48. Levers K, Dalton R, Galvan E, O'Connor A, Goodenough C, Simbo S, et al. Effects of powdered Montmorency tart cherry supplementation on acute endurance exercise performance in aerobically trained individuals. J Int Soc Sports Nutr. 2016;13:22.
  49. Howatson G, McHugh MP, Hill JA, Brouner J, Jewell AP, van Someren KA, et al. Influence of tart cherry juice on indices of recovery following marathon running. Scand J Med Sci Sports. 2010;20(6):843-52.
  50. Kurtz JA, VanDusseldorp TA, Doyle JA, Otis JS. Taurine in sports and exercise. J Int Soc Sports Nutr. 2021;18(1):39.
  51. Cabrera Á J. Zinc, aging, and immunosenescence: an overview. Pathobiology of aging & age related diseases. 2015;5:25592.
  52. Morin CM. Cognitive-behavioral approaches to the treatment of insomnia. J Clin Psychiatry. 2004;65(Suppl 16):33-40.
  53. Stepanski EJ. Causes of insomnia. Sleep: A comprehensive handbook. 2006:99-102.
  54. Irish LA, Kline CE, Gunn HE, Buysse DJ, Hall MH. The role of sleep hygiene in promoting public health: A review of empirical evidence. Sleep Med Rev. 2015;22:23-36.
  55. Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, Ozeki M, et al. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019;11(10).
  56. Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biological psychology. 2007;74(1):39-45.
  57. Rogers PJ, Smith JE, Heatherley SV, Pleydell-Pearce CW. Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together. Psychopharmacology. 2008;195(4):569-77.
  58. Unno K, Tanida N, Ishii N, Yamamoto H, Iguchi K, Hoshino M, et al. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress. Pharmacology, biochemistry, and behavior. 2013;111:128-35.
  59. Everett JM, Gunathilake D, Dufficy L, Roach P, Thomas J, Upton D, et al. Theanine consumption, stress and anxiety in human clinical trials: A systematic review. Journal of Nutrition & Intermediary Metabolism. 2016;4:41-2.
  60. Abdou AM, Higashiguchi S, Horie K, Kim M, Hatta H, Yokogoshi H. Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. Biofactors. 2006;26(3):201-8.
  61. Kim S, Jo K, Hong K-B, Han SH, Suh HJ. GABA and l-theanine mixture decreases sleep latency and improves NREM sleep. Pharmaceutical biology. 2019;57(1):64-72.
  62. Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences. 2012;17(12):1161-9.
  63. Held K, Antonijevic IA, Künzel H, Uhr M, Wetter TC, Golly IC, et al. Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Pharmacopsychiatry. 2002;35(4):135-43.
  64. Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, Zheng Y, et al. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Human psychopharmacology. 2022;37(6):e2852.
  65. Durrani D, Idrees R, Idrees H, Ellahi A. Vitamin B6: A new approach to lowering anxiety, and depression? Annals of medicine and surgery (2012). 2022;82:104663.
  66. Akhtar MI, Ullah H, Hamid M. Magnesium, a drug of diverse use. Journal of the Pakistan Medical Association. 2011;61(12):1220.
  67. Pérez-Torres I, María Zuniga-Munoz A, Guarner-Lans V. Beneficial effects of the amino acid glycine. Mini reviews in medicinal chemistry. 2017;17(1):15-32.
  68. Wu GF, Ren S, Tang RY, Xu C, Zhou JQ, Lin SM, et al. Antidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats. Sci Rep. 2017;7(1):4989.
  69. Kong WX, Chen SW, Li YL, Zhang YJ, Wang R, Min L, et al. Effects of taurine on rat behaviors in three anxiety models. Pharmacology, biochemistry, and behavior. 2006;83(2):271-6.
  70. Fraigne JJ, Torontali ZA, Snow MB, Peever JH. REM sleep at its core–circuits, neurotransmitters, and pathophysiology. Frontiers in neurology. 2015;6:123.
  71. Li C, Tong H, Yan Q, Tang S, Han X, Xiao W, et al. L-Theanine improves immunity by altering TH2/TH1 cytokine balance, brain neurotransmitters, and expression of phospholipase C in rat hearts. Medical science monitor: international medical journal of experimental and clinical research. 2016;22:662.
  72. Wu J-Y, Prentice H. Role of taurine in the central nervous system. Journal of biomedical science. 2010;17(1):1-6.
  73. Nartsissov YR. Amino Acids as Neurotransmitters. The Balance between Excitation and Inhibition as a Background for Future Clinical Applications. COVID-19, Neuroimmunology and Neural Function. 2022:81.
  74. Zeng L, Lin L, Peng Y, Yuan D, Zhang S, Gong Z, et al. l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation. Experimental Gerontology. 2020;131:110823.
  75. Edwards C, Canfield J, Copes N, Brito A, Rehan M, Lipps D, et al. Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans. BMC genetics. 2015;16(1):8.
  76. Saper CB, Chou TC, Scammell TE. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci. 2001;24(12):726-31.
  77. Bannai M, Kawai N, Ono K, Nakahara K, Murakami N. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Frontiers in neurology. 2012;3:61.
  78. Inagawa K, Hiraoka T, Kohda T, Yamadera W, Takahashi M. Subjective effects of glycine ingestion before bedtime on sleep quality. Sleep and Biological Rhythms. 2006;4(1):75-7.
  79. Liu YJ, Janssens GE, McIntyre RL, Molenaars M, Kamble R, Gao AW, et al. Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion. PLoS Genet. 2019;15(3):e1007633.
  80. Tardy AL, Pouteau E, Marquez D, Yilmaz C, Scholey A. Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence. Nutrients. 2020;12(1).
  81. Ge L, Luo J, Zhang L, Kang X, Zhang D. Association of Pyridoxal 5'-Phosphate with Sleep-Related Problems in a General Population. Nutrients. 2022;14(17).
  82. Pouteau E, Kabir-Ahmadi M, Noah L, Mazur A, Dye L, Hellhammer J, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13(12):e0208454.
  83. Choi E-J, Tang Y, Lee CB, Cheong SH, Park P-J, Moon S-H, et al., editors. Investigation of Antioxidant and Anticancer Potential of Taurine by Means of Multiple Chemical and Biological Assays. Taurine 9; 2015 2015//; Cham: Springer International Publishing.
  84. Hartmann E, Spinweber CL. Sleep induced by L-tryptophan. Effect of dosages within the normal dietary intake. The Journal of nervous and mental disease. 1979;167(8):497-9.
  85. Hartmann E. Effects of L-tryptophan on sleepiness and on sleep. Journal of psychiatric research. 1982;17(2):107-13.
  86. Pigeon WR, Carr M, Gorman C, Perlis ML. Effects of a tart cherry juice beverage on the sleep of older adults with insomnia: a pilot study. J Med Food. 2010;13(3):579-83.
  87. Pelletier MGH, Szymczak K, Barbeau AM, Bishop EJ, Johnson BB, Lee AJ, et al. Tart cherry extract improves skeletal muscle recovery by increasing type II MHC expression, MCP-1 and HGF secretion, and attenuating ROS production by neutrophils. The Journal of Immunology. 2018;200(1_Supplement):46.20-46.20.
  88. Cherasse Y, Urade Y. Dietary Zinc Acts as a Sleep Modulator. Int J Mol Sci. 2017;18(11).
  89. Hajianfar H, Mollaghasemi N, Tavakoly R, Campbell MS, Mohtashamrad M, Arab A. The association between dietary zinc intake and health status, including mental health and sleep quality, among Iranian female students. Biological Trace Element Research. 2021;199:1754-61.
  90. Yamadera W, Inagawa K, Chiba S, Bannai M, Takahashi M, Nakayama K. Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep and Biological Rhythms. 2007;5:126-31.
  91. Yu S, Gao L, Song Y, Ma X, Liang S, Lan H, et al. Glycine ameliorates mitochondrial dysfunction caused by ABT-199 in porcine oocytes. Journal of Animal Science. 2021;99(4).
  92. Tamano H, Fukura K, Suzuki M, Sakamoto K, Yokogoshi H, Takeda A. Advantageous effect of theanine intake on cognition. Nutr Neurosci. 2014;17(6):279-83.
  93. Unno K. Prevention of brain aging by green tea components: Role of catechins and theanine. The Journal of Physical Fitness and Sports Medicine. 2016;5:117-22.
  94. Attia S. Modulation of irinotecan-induced genomic DNA damage by theanine. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012;50(5):1749-54.
  95. Petrović J, Stanić D, Dmitrašinović G, Plećaš-Solarović B, Ignjatović S, Batinić B, et al. Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man. Oxidative Medicine and Cellular Longevity. 2016;2016:2019643.
  96. Rondanelli M, Opizzi A, Monteferrario F, Antoniello N, Manni R, Klersy C. The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial. J Am Geriatr Soc. 2011;59(1):82-90.
  97. Ha CR, Kim SH, Na SB, You JS, Chang KJ, editors. The Association Among Dietary Taurine Intake, Obesity and Quality of Sleep in Korean Women. Taurine 9; 2015 2015//; Cham: Springer International Publishing.
  98. Lemoine P, Bablon J-C, Da Silva C. A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study. Complementary Therapies in Medicine. 2019;45:104-8.

  • Free Shipping

    Free shipping to the continental US with all subscriptions.

    Learn more

  • 90-Day Guarantee

    Risk-free results—love it or get a full refund.

    See policy

  • Subscribe & Save

    Enjoy exclusive savings on every order. Cancel anytime.

    view terms