Resveratrol has shown great potential in extending lifespan and promoting healthy aging.

Dr. Jane Doe, Longevity Researcher.

Making scientific discoveries accessible to all

Did you know. There’s a whole world inside your stomach. It’s called your gut microbiome.

Resveratrol, a naturally occurring polyphenol, has garnered significant attention for its potential to mimic the effects of caloric restriction, a well-known method for extending lifespan. Historically found in the skin of red grapes, resveratrol is also present in berries and peanuts.

Now you know how hard the gut is working every day, here are five things the gut microbiome can do that you probably didn’t realise. Until now.

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Gamma-aminobutyric acid, an amino acid that controls feelings of fear and anxiety, is another component produced in the gut. It’s known to reduce natural libido, causing a potential lull in sex drive. Keeping the gut microbiome well-fed with good gut bacteria supports the production of serotonin by ensuring good bacteria and your mood are in positive balance. Let’s GUT it on.

How Resveratrol Impacts Aging:

Specific Hallmarks:

  • Cellular Senescence: Reduces the accumulation of senescent cells, which are associated with aging and tissue dysfunction.
  • Mitochondrial Dysfunction: Enhances mitochondrial efficiency, supporting energy metabolism and reducing oxidative stress.
  • Mechanism of Action:
    Improved Sleep: Regulates the sleep-wake cycle, leading to better sleep quality.
  • Tissue Regeneration: Promotes collagen production, improving skin health and reducing signs of aging.
  • Moisture Retention: Reduces oxidative stress, which helps maintain skin moisture and elasticity.

Scientific studies

  • Effects of intermittent fasting on disease processes and general health

    Intermittent fasting (IF)  means regularly going through extended periods (e.g., 16–48 hours) without eating or consuming very little energy, followed by regular meals. In experimental models of a wide range of age-related disorders, including diabetes, cardiovascular disease, cancers, and neurological conditions such as Alzheimer's disease, Parkinson's disease, and stroke, IF positively affects health in laboratory rats and mice. IF can also counteract disease processes and improve functional outcomes. Studies on fasting in normal and overweight humans have shown that it effectively reduces body weight and enhances a number of health indicators, such as insulin resistance and cardiovascular disease risk factors (9, 24).

  • Effects of Caloric Restriction on the Hallmarks of Aging

    By enhancing cell survival, reducing cell proliferation, and inducing stem cell quiescence and autophagy, caloric restriction increases lifespan and preserves the stem cell reserve for urgent needs (25-27).

  • The electrolyte levels during fasting

    Typically, our body excretes potassium and sodium through urine when we fast for extended durations. Any fast that lasts longer than 12 hours may result in those electrolytes deficit (11).

  • Different dietary fibers remodel gut microbiota and charge up anti-obesity effects

    Dietary fiber is well known as a food component that promotes good health through changes in the composition and function of the gut microflora. Different types of dietary fiber can differentially affect those bacteria and change how glucose and lipid metabolism is regulated (28).

  • Reference link

    Beta-hydroxybutyrate (BHB) as an anti-aging substance

    BHB is a signaling molecule that modulates lipolysis, oxidative stress, and neuroprotection. It serves as an energy substrate for maintaining metabolic homeostasis. It delays many age-related disorders by acting as an epigenetic regulator of histone methylation, acetylation, and beta-hydroxybutyrylation. Additionally, research suggests that exogenous supplementation or endogenous BHB administration successfully induces an ametabolic state of nutritional ketosis (13, 23).

Recommended Dosage

250-500 mg

per day

Estimated Amount Needed

~40

glasses of red wine

You would have to consume approximately 40 glasses of red wine to obtain the same amount of resveratrol in one daily dose of Longevity Foundation.

Source and origin

Resveratrol is primarily found in the skin of red grapes, berries, and peanuts.Resveratrol occurs naturally in some plant foods. You can add resveratrol to your diet by eating foods like peanuts, grapes, blueberries, raspberries, and mulberries. Red wine is also a good source of resveratrol. You can also find resveratrol supplements in the vitamin section of your grocery store.

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Resveratrol found in

Resveratrol is a key ingredient in our Longevity Foundation due to its proven benefits in promoting cellular health and longevity.

Resveratrol might have many effects in the body, including expanding blood vessels and reducing blood clotting.

Resveratrol is a potent antioxidant found in red wine and grapes, renowned for its anti-aging and longevity benefits.

  • Promotes cellular health and longevity by activating sirtuins.
  • Enhances cardiovascular health by improving blood flow and reducing inflammation.
  • Supports cognitive function and protects against neurodegenerative diseases.

People Also Ask

  • Does resveratrol increase longevity?

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  • Can resveratrol reverse skin aging?

    The resveratrol emulsion shows positive outcomes by supporting reduction of skin wrinkling and increasing skin firmness, as well as reducing skin redness, and is therefore an all-round anti-aging treatment.

    Learn more about this in our article Skin & Longevity: The Relationship Between Skin and Healthy Aging

  • Does resveratrol increase testosterone?

  • Does resveratrol increase telomeres?

  • Does resveratrol boost collagen?

References

  • Reference link

    1. Gu L, Fu R, Hong J, Ni H, Yu K, Lou H. Effects of Intermittent Fasting in Human Compared to a Non-intervention Diet and Caloric Restriction: A Meta-Analysis of Randomized Controlled Trials. Front Nutr. 2022;9:871682.

  • 2. Fontana L, Meyer TE, Klein S, Holloszy JO. Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc Natl Acad Sci U S A. 2004;101(17):6659-63.

  • 3. Attinà A, Leggeri C, Paroni R, Pivari F, Dei Cas M, Mingione A, et al. Fasting: How to guide. Nutrients. 2021;13(5):1570.

  • 4. Waziry R, Ryan CP, Corcoran DL, Huffman KM, Kobor MS, Kothari M, et al. Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial. Nature Aging. 2023;3(3):248-57.

  • 5. Calabrese EJ, Dhawan G, Kapoor R, Iavicoli I, Calabrese V. What is hormesis and its relevance to healthy aging and longevity? Biogerontology. 2015;16(6):693-707.

  • 6. Vaiserman AM. Hormesis, adaptive epigenetic reorganization, and implications for human health and longevity. Dose-Response. 2010;8(1):dose-response. 09-014. Vaiserman.

  • 7. Mattson MP. Challenging oneself intermittently to improve health. Dose Response. 2014;12(4):600-18.

  • 8. Shetty AK, Kodali M, Upadhya R, Madhu LN. Emerging Anti-Aging Strategies - Scientific Basis and Efficacy. Aging Dis. 2018;9(6):1165-84.

  • 9. Mattson MP, Longo VD, Harvie M. Impact of intermittent fasting on health and disease processes. Ageing Res Rev. 2017;39:46-58.

  • Reference link

    10. Mirzababaei A, Zandkarimi R, Moradi S, Rasaei N, Amini MR, Pourreza S, et al. The effect of Glucomannan on fasting and postprandial blood glucose in adults: a systematic review and meta-analysis of randomized controlled trials. Journal of diabetes and metabolic disorders. 2022;21(1):1055-63.

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