"Mulberry leaves promote metabolic health by activating AMP-activated protein kinase (AMPK), enhancing mitochondrial function, and improving glucose metabolism."

Dr. Long Cheng & team (2021), from their findings in the British Journal of Nutrition on mulberry leaf’s role in regulating energy metabolism

White Mulberry Leaf: Unlocking the Secrets to Longevity and Health

White Mulberry Leaf's longevity-promoting properties can be traced to its rich profile of bioactive compounds, including flavonoids, alkaloids, and a unique compound known as 1-deoxynojirimycin (DNJ). These constituents interact with the body at a cellular level, targeting the processes that influence aging and metabolic health.

Regulating Blood Sugar Levels for Long-Term Health: Maintaining stable blood sugar levels is critical for preventing metabolic imbalances that accelerate aging. Studies show that DNJ in White Mulberry Leaf inhibits the enzymes alpha-glucosidase and alpha-amylase, which break down carbohydrates into glucose, resulting in reduced postprandial blood sugar spikes (Kimura et al., 2007).

A clinical trial revealed that White Mulberry Leaf extract significantly lowered glycemic and insulinemic responses in healthy individuals, supporting its role in metabolic health (Thondre et al., 2021). Stable blood sugar levels reduce the formation of advanced glycation end-products (AGEs), harmful compounds linked to inflammation, oxidative stress, and aging (Li et al., 2021).

Enhancing Mitochondrial Function and Energy Production: Mitochondria, often called the "powerhouses of the cell," play a critical role in energy production and cellular health. White Mulberry Leaf activates the AMP-activated protein kinase (AMPK) pathway, which boosts mitochondrial function and improves glucose uptake (Meng et al., 2020). Better mitochondrial health is associated with increased cellular energy, reduced oxidative damage, and slower aging.

Antioxidant Defense Against Cellular Aging: Oxidative stress, caused by free radicals, damages cells and accelerates aging. White Mulberry Leaf is rich in phenolic compounds and flavonoids, such as quercetin and chlorogenic acid, which neutralize free radicals and reduce oxidative stress (Katsube et al., 2010).

A study on diabetic rats showed significant improvements in markers of oxidative stress and enhanced antioxidant enzyme activity, supporting its potential as an anti-aging agent (Andallu & Varadacharyulu, 2003).

Metabolic Regulation and Lipid Profile Improvement

Elevated cholesterol and triglycerides are major risk factors for age-related diseases. White Mulberry Leaf has shown the ability to improve lipid profiles by lowering LDL cholesterol and increasing HDL cholesterol in clinical studies (Andallu et al., 2001). These benefits enhance cardiovascular health, a cornerstone of longevity.

Gut Health and Microbiome Support

Emerging research highlights the role of gut health in aging. White Mulberry Leaf has been shown to modulate the gut microbiota, promoting beneficial bacteria and reducing harmful strains associated with inflammation and insulin resistance (Sheng et al., 2017).

Broader Health Benefits of White Mulberry Leaf

Beyond its longevity-promoting properties, White Mulberry Leaf offers a range of health benefits that align with a holistic approach to wellness:

Weight Management: By improving glucose metabolism and reducing insulin resistance, White Mulberry Leaf may support healthy weight management and metabolic balance. Research also indicates its role in promoting "browning" of white adipose tissue, enhancing energy expenditure (Cheng et al., 2021).

Liver and Kidney Protection: Chronic high blood sugar can lead to organ damage. White Mulberry Leaf reduces markers of liver and kidney damage, supporting overall organ health (Zhang et al., 2019).

Inflammation Reduction: Chronic inflammation is a known driver of aging and diseases like arthritis, diabetes, and heart disease. White Mulberry Leaf inhibits pro-inflammatory pathways, including the NF-ÎşB and p38 MAPK signaling pathways, reducing systemic inflammation (Li et al., 2021).

The Promise of White Mulberry Leaf in Longevity Science

White Mulberry Leaf is a remarkable botanical ingredient that bridges traditional wisdom and modern science. Its ability to regulate blood sugar, combat oxidative stress, enhance mitochondrial function, and support cardiovascular health positions it as a cornerstone for those seeking to optimize their healthspan.

While White Mulberry Leaf should not be viewed as a cure for any disease, its science-backed benefits make it a valuable addition to a holistic longevity-focused lifestyle. As research continues to unravel its full potential, this humble leaf stands tall as a symbol of natural wellness and vitality.

How White Mulberry Leaves Impacts Aging:

Specific Hallmarks:

  • Loss of Proteostasis: White Mulberry Leaf reduces oxidative stress, protecting proteins from damage and supporting proper protein folding (Andallu & Varadacharyulu, 2003).
  • Deregulated Nutrient Sensing: It activates the AMPK pathway, improving glucose metabolism and reducing insulin resistance, a key factor in healthy aging (Meng et al., 2020).
  • Mitochondrial Dysfunction: Enhances mitochondrial function and energy production by boosting AMPK signaling, mitigating age-related declines (Meng et al., 2020).
  • Cellular Senescence: Its antioxidant and anti-inflammatory properties may help reduce the accumulation of senescent cells linked to chronic inflammation (Li et al., 2021).
  • Inflammatory Responses: Modulates the NF-ÎşB and p38 MAPK pathways to lower systemic inflammation, a hallmark of aging (Li et al., 2021).

Mechanism of Action:

  • Improved Blood Sugar Control: Regulates glucose levels post-meals, reducing sugar spikes and enhancing insulin sensitivity (Thondre et al., 2021).
  • Enhanced Metabolism: Promotes fat metabolism and energy expenditure by inducing browning of white adipose tissue (Cheng et al., 2021).
  • Liver and Kidney Health: Protects against oxidative damage in these critical organs, supporting detoxification and metabolic health (Zhang et al., 2019).
  • Anti-Inflammatory Benefits: Reduces markers of inflammation through bioactive compounds like flavonoids, which calm systemic inflammation (Li et al., 2021).
  • Antioxidant Power: Boosts the body's defense against oxidative stress, increasing activity of enzymes like SOD and glutathione peroxidase (Andallu & Varadacharyulu, 2003).

Scientific studies

  • Reference link

    Mulberry Leaf Extract Lowers Postprandial Blood Sugar Levels

    Researchers conducted a randomized, double-blind, placebo-controlled study to test the effect of white mulberry leaf extract on glycemic response. Thirty-eight healthy participants consumed 75g of sucrose with or without mulberry leaf extract. Results showed significantly reduced postprandial blood glucose and insulin levels in the mulberry group, indicating its potential to support healthy glucose metabolism and insulin sensitivity. This study highlights the ingredient's role in blood sugar management, a critical factor in longevity. Reference: Published in Nutrition & Metabolism (2021), titled “Mulberry Leaf Extract Improves Glycaemic Response and Insulaemic Response to Sucrose,”

  • Flavonoids in White Mulberry Leaf Improve Mitochondrial Function

    This study investigated the effects of flavonoids extracted from mulberry leaves on skeletal muscle in diabetic mice and cell models. Findings demonstrated enhanced glucose uptake, improved mitochondrial function, and activated AMPK pathways, which are vital for energy production and metabolic health. These results suggest that white mulberry leaf flavonoids may combat mitochondrial dysfunction, a hallmark of aging. Reference: Published in Journal of Ethnopharmacology (2020), titled “Flavonoids Extracted from Mulberry (Morus alba L.) Leaf Improve Skeletal Muscle Mitochondrial Function,”

  • Reference link

    Mulberry Leaf Polyphenols Extend Lifespan in C. elegans

    Using a C. elegans model, researchers showed that mulberry leaf polyphenols (MLPs) delayed aging, improved resistance to oxidative stress, and reduced fat storage. The effects were attributed to the germline signaling pathway and transcription factors that regulate longevity-related genes. This study provides compelling evidence for MLP’s anti-aging properties. Reference: Published in AGE (2014), titled “Mulberry Leaf Polyphenols Delay Aging and Regulate Fat Metabolism,”

  • Reference link

    Mulberry Leaf Activates Brown Adipose Tissue for Metabolic Benefits

    A study in diabetic rats demonstrated that mulberry leaf induced browning of white adipose tissue and activated brown adipose tissue, enhancing metabolic function. By activating the AMPK pathway and increasing mitochondrial biogenesis, mulberry leaf improved glucose and lipid metabolism, suggesting its role in managing metabolic dysfunctions linked to aging. Reference: Published in British Journal of Nutrition (2021), titled “Mulberry Leaf Activates Brown Adipose Tissue and Induces Browning of White Adipose Tissue,”

Recommended Dosage

200-250 mg

per day

Estimated Amount Needed

~40-100 g

of raw Mulberry Leaf

You would have to consume approximately 40-100g of raw Mulberry leaf to obtain the same amount in one daily dose of Glucose Blocker.

Source and origin

White Mulberry Leaf is most commonly found on the Morus alba tree, native to China, where its leaves contain the highest concentrations of beneficial compounds like 1-deoxynojirimycin (DNJ), flavonoids, and polyphenols, making it a potent source for health and longevity benefits

People Also Ask

  • What is White Mulberry Leaf, and where does it come from?

    White Mulberry Leaf comes from the Morus alba tree, native to China but now cultivated globally. It has been used in traditional medicine for centuries due to its rich content of beneficial compounds like flavonoids, alkaloids, and 1-deoxynojirimycin (DNJ).

  • How does White Mulberry Leaf benefit metabolic health?

    White Mulberry Leaf inhibits enzymes like alpha-glucosidase, slowing carbohydrate digestion and absorption, which helps manage post-meal blood sugar spikes and improves insulin sensitivity.

  • Can White Mulberry Leaf support weight management?

    Yes, by improving glucose metabolism and promoting fat oxidation, White Mulberry Leaf can aid in maintaining a healthy weight and preventing fat accumulation.

  • How does White Mulberry Leaf contribute to cardiovascular health?

    By reducing LDL cholesterol and triglycerides and increasing HDL cholesterol, White Mulberry Leaf supports heart health and vascular function.

  • Is White Mulberry Leaf suitable for people without blood sugar issues?

    Absolutely. Even for individuals without metabolic conditions, its antioxidant and anti-inflammatory effects can contribute to overall cellular health and longevity.

  • What makes White Mulberry Leaf unique compared to other herbal supplements?

    Its high concentration of DNJ and unique blend of antioxidants and bioactive compounds give it specific advantages in regulating blood sugar and supporting multiple longevity pathways.

  • Are there any known interactions with medications?

    White Mulberry Leaf may interact with diabetes medications, enhancing their effects. It’s important to consult a healthcare provider before use if taking any blood sugar-lowering drugs or other medications.

Glucose Blocker

A powerhouse formula designed to stabilize glucose, crush cravings, and fuel fat burn for lasting metabolic longevity. Clinically studied ingredients activate AMPK to convert fat into energy, curb carb absorption, and turbocharge metabolism—so you can enjoy carbs without the crash.

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White Mulberry Leaves found in

White Mulberry Leaf is a key component in our Glucose Blocker due to its clinically proven benefits in supporting healthy blood sugar levels and promoting metabolic longevity. Administered at the optimal dose of 200 mg, this powerful ingredient works synergistically with other compounds in the formulation to inhibit carbohydrate absorption, stabilize post-meal glucose levels, and combat oxidative stress—key factors in maintaining vitality and supporting long-term health

References

  • Reference link

    Andallu, B., & Varadacharyulu, N. (2003). Antioxidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin-diabetic rats. Clinica Chimica Acta; International Journal of Clinical Chemistry, 338(1-2), 3-10.

  • Andallu, B., Suryakantham, V., Lakshmi Srikanthi, B., & Reddy, G. (2001). Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clinica Chimica Acta; International Journal of Clinical Chemistry, 314(1-2), 47-53.

  • Cheng, L., Wang, J., An, Y., Dai, H., Duan, Y., Shi, L., Lv, Y., Li, H., Wang, C., Du, H., Zhong, X., & Zhao, B. (2021). Mulberry leaf activates brown adipose tissue and induces browning of inguinal white adipose tissue in type 2 diabetic rats through regulating AMP-activated protein kinase signaling pathway. British Journal of Nutrition, 127, 810-822.

  • Kimura, T., Nakagawa, K., Kubota, H., Kojima, Y., Goto, Y., Yamagishi, K., Oita, S., Oikawa, S., & Miyazawa, T. (2007). Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. Journal of Agricultural and Food Chemistry, 55(14), 5869-5874.

  • Katsube, T., Yamasaki, M., Shiwaku, K., Ishijima, T., Matsumoto, I., Abe, K., & Yamasaki, Y. (2010). Effect of flavonol glycoside in mulberry (Morus alba L.) leaf on glucose metabolism and oxidative stress in the liver in diet-induced obese mice. Journal of the Science of Food and Agriculture, 90(14), 2386-2392.

  • Li, J.-S., Ji, T., Su, S., Zhu, Y., Chen, X., Shang, E., Guo, S., Qian, D., & Duan, J. (2021). Mulberry leaves ameliorate diabetes via regulating metabolic profiling and AGEs/RAGE and p38 MAPK/NF-ÎşB pathway. Journal of Ethnopharmacology, 114713.

  • Meng, Q., Qi, X., Fu, Y., Chen, Q., Cheng, P., Yu, X., Sun, X., Wu, J., Li, W., Zhang, Q., Li, Y., & Bian, H. (2020). Flavonoids extracted from mulberry (Morus alba L.) leaf improve skeletal muscle mitochondrial function by activating AMPK in type 2 diabetes. Journal of Ethnopharmacology, 112326.

  • Riche, D., Riche, K. D., East, H., Barrett, E., & May, W. (2017). Impact of mulberry leaf extract on type 2 diabetes (Mul-DM): A randomized, placebo-controlled pilot study. Complementary Therapies in Medicine, 32, 105-108.

  • Sheng, Y., Zheng, S., Ma, T., Zhang, C., Ou, X., He, X., Xu, W., & Huang, K. (2017). Mulberry leaf alleviates streptozotocin-induced diabetic rats by attenuating NEFA signaling and modulating intestinal microflora. Scientific Reports, 7, Article 12245.

  • Thondre, P., Lightowler, H., Ahlstrom, L., & Gallagher, A. (2021). Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: Results of a randomized, double-blind, placebo-controlled study. Nutrition & Metabolism, 18, Article 571.

  • Zhang, L., Su, S., Zhu, Y., Guo, J., Guo, S., Qian, D., Ouyang, Z., & Duan, J. (2019). Mulberry leaf active components alleviate type 2 diabetes and its liver and kidney injury in db/db mice through insulin receptor and TGF-β/Smads signaling pathway. Biomedicine & Pharmacotherapy, 112, Article 108675.

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