Cellular Skin Renewal
Cellular Skin Renewal
Cellular Skin Renewal
Cellular Skin Renewal
Cellular Skin Renewal
Cellular Skin Renewal
Cellular Skin Renewal
Cellular Skin Renewal
Cellular Skin Renewal
Cellular Skin Renewal
Cellular Skin Renewal
Cellular Skin Renewal
Cellular Skin Renewal
Cellular Skin Renewal
Cellular Skin Renewal
Cellular Skin Renewal
SKIN RENEWAL PROTOCOL

Cellular Skin Renewal

4.9/5
| 1155+ Verified Reviews
$81per month

The all-in-one skin longevity supplement—targets the root causes of skin aging from the inside out. Clinically proven ingredients boost collagen, replenish NAD+, and enhance hyaluronic acid, while clearing age-accelerating senescent cells. Experience the next generation of skin anti-aging, for firmer, smoother, more radiant skin—at the cellular level.

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Product description

Cellular Skin Renewal goes where topicals can’t, tackling the root causes of skin aging at a cellular level. A complete skin anti-aging protocol featuring 9 clinically studied ingredients, this first-of-its-kind all-in-one formula boosts collagen production, NAD+, and hyaluronic acid, while neutralizing aging accelerators like senescent zombie cells and oxidative stress—delivering longer lasting, visibly smoother, firmer, and more youthful skin from the inside out.

  • Clinically proven ingredients to reduce wrinkles by 32% in just 8 weeks
  • Boosts collagen, elastin & hyaluronic acid—supports 65% more procollagen type I for firmer, deeply hydrated skin.
  • Sunblock in a supplement—built-in UV defense with antioxidants 6,000x more potent than Vitamin C
  • Clears senescent ‘zombie’ cells to accelerate renewal & promote lasting skin longevity
  • Strengthens hair & nails—11% thicker hair, 12% faster nail growth, and 42% less breakage.

Ingredient list

VERISOL® collagen peptides 2500 mg
Niacin (as niacinamide, NAD+ Booster) 500 mg
Hyaluronic acid (as sodium hyaluronate) 150 mg
Vitamin C (as ascorbic acid) 150 mg
Vitamin E (as dl-alpha-tocopheryl acetate) 30 mg
N-Acetyl-D-Glucosamine 500 mg
CeraLOK™ rice-derived ceramides 40 mg
AstaZine® Astaxanthin (from algae) 3.5 mg
Spermidine (HCl) 1 mg

Suggested use

How to use

Mix one scoop with one cup (8fl oz) water. Take Cellular Skin Renewal daily.

Behavioral protocol

Ensure a balanced diet, sufficient sleep, and effective stress management. Stay hydrated by drinking ample water - hydration is an internal process: topicals will only trap water on the outside. Avoid smoking, vaping, or diets high in sugar, as these habits can lead to premature skin aging.

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More than just a supplement—your purchase unlocks exclusive skin longevity guidance, delivered straight to your inbox. Get science-backed anti-aging strategies, cutting-edge rejuvenation research, and expert insights to help you achieve youthful, resilient, and biologically healthy skin—powered by real science.

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Boost your routine
Cellular Skin Renewal
Ingredients
Vitamin C (as ascorbic acid)
150 mg
Vitamin E (as dl-alpha-tocopheryl acetate)
30 mg
Niacin (as niacinamide)
500 mg
VERISOL® collagen peptides
2,500 mg
N-Acetyl-D-Glucosamine (NAG)
500 mg
Hyaluronic acid (as sodium hyaluronate)
150 mg
CeraLOK® rice ceramide powder
40 mg
AstaZine® Astaxanthin (from Haematococcus pluvialis algae extract)
3.5 mg
Spermidine HCl
1 mg

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Complete Cellular Skin Revival, One Scoop a Day

Clinically proven ingredients to firm skin, smooth wrinkles, and restore radiance from within.

Your complete skin renewal protocol

Discover the unique benefits that set us apart.

Clinically Proven Collagen Renewal

Visibly Reduce Wrinkles, Cellulite, and Sagging

Unlike ordinary collagen powders—which get broken down into amino acids and don’t specifically target skin regeneration (1,2)—Cellular Skin Renewal features patented Verisol® collagen peptides that directly activate your skin’s fibroblasts, the cells responsible for collagen production. Clinical studies show remarkable, measurable results:

  • 32% reduction in wrinkle depth and 23% in wrinkle volume after just 8 weeks (25).
  • 10% improvement in skin elasticity after 4 weeks, with lasting effects even weeks after stopping supplementation (4).
  • 11.1% reduction in cellulite severity and increased skin firmness after 6 months (6).
  • 11% increase in hair thickness over 16 weeks (70).
  • 42% decrease in nail breakage and 12% faster nail growth (71).

For even greater effectiveness, Cellular Skin Renewal combines Verisol® with Vitamin C (essential for collagen formation (7)), Niacinamide (boosts collagen and enhances skin texture (8)), and Spermidine (promotes collagen synthesis and restores skin’s structure (9)). This synergistic blend ensures firmer, visibly smoother skin, supported by real clinical outcomes.

All references

Radical Hydration from Within

Restore Lasting Hydration—Beyond Topical Creams

True hydration—the kind that visibly smooths wrinkles and restores youthful plumpness—begins beneath your skin’s surface. Unlike topical creams that merely trap moisture temporarily, Cellular Skin Renewal deeply hydrates skin from within using Hyaluronic Acid (HA), nature’s ultimate moisture magnet, proven to enhance internal hydration and reduce fine lines (10,11). It also boosts your body’s natural HA production through N-Acetyl-D-glucosamine, an advanced HA precursor with exceptional bioavailability (58,59). Complementing this internal hydration powerhouse, clinically validated CeraLOK® ceramides strengthen your skin’s moisture barrier to prevent water loss, leaving your skin noticeably smoother, firmer, and more radiant (12).

All references

Boost NAD+ for Energized, Youthful Skin

Recharge Skin Cells From Within with Longevity Science

NAD+ is vital for youthful skin—but levels naturally decline with age, weakening your skin’s energy and ability to repair damage. Cellular Skin Renewal tackles this challenge head-on with Niacinamide, a powerful precursor that replenishes NAD+ within your skin cells (14-16). By restoring NAD+, it enhances cellular energy, activates DNA repair, and stimulates anti-aging proteins called sirtuins (including SIRT1 and SIRT3) that boost collagen, calm inflammation, and defend against UV damage (14-16). The result: visibly younger-looking, healthier, and more resilient skin—revitalized from the inside out.

All references

Clear Aging 'Zombie' Cells

Clear Senescent Cells for Smoother, Younger-Looking Skin

Your skin is ground zero for aging 'zombie' cells—damaged cells that accumulate from environmental stress, causing wrinkles, uneven tone, rough texture, and slower regeneration (17,18). Worse still, these harmful cells release inflammatory proteins that accelerate whole-body aging, impacting organs from your heart to your brain (19-21). 

Spermidine naturally boosts autophagy—your skin's powerful internal cleansing and renewal process that removes damaged, aging cells and accumulated debris. By ramping up autophagy, spermidine visibly improves texture, tone, and elasticity, restoring a smoother, brighter, more youthful complexion (22,23). This remarkable cellular rejuvenation not only revitalizes your skin’s appearance but actively counters underlying processes that accelerate aging.

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Internal Sun Protection & Antioxidant Defense

Defend from UV Damage with Nature’s Most Powerful Antioxidants

Think of Astaxanthin as your internal sunblock—naturally accumulating in your skin to shield cells from UV damage and environmental stress (36,37). With antioxidant strength up to 6000 times greater than Vitamin C, Astaxanthin powerfully neutralizes harmful free radicals, reducing inflammation and helping prevent signs of sun-related aging (36,37). Vitamins C and E amplify this defense by strengthening your skin’s resilience to sun exposure, reducing UV-induced damage, and supporting your skin’s natural healing and recovery processes (7,24,33-35). Together, they offer comprehensive, internal protection for visibly healthier, younger-looking skin.

All references

Even Skin Tone & Reduce Dark Spots

Brighten your complexion and visibly fade age spots

Cellular Skin Renewal corrects uneven pigmentation from the inside out with a powerful blend of Vitamin C, Niacinamide, and CeraLOK® ceramides. Vitamin C brightens and evens skin by reducing melanin production (7). Niacinamide further diminishes dark spots by interrupting pigment transfer between skin cells (47), while clinically proven CeraLOK® ceramides enhance skin barrier function, texture, and radiance (31). The result: visibly brighter, smoother, and more even-toned skin.

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Fight Sugar-Triggered Wrinkles

Slow Slycation to Visibly Protect Skin Elasticity and Smoothness

Eating sugar (or carbs!) causes "glycation," a damaging process where sugar molecules bind to collagen and elastin, causing stiff, sagging, and wrinkled skin (48). Cellular Skin Renewal directly blocks glycation using N-Acetyl-D-glucosamine, which prevents sugars from attaching to your skin’s vital proteins (48). It also features Niacinamide, proven to inhibit glycation reactions and collagen breakdown (50), alongside antioxidant Vitamins C and E, further shielding skin from sugar-induced aging (49,50). The result: smoother, younger-looking skin, protected against sugar-related aging.

All references

How to use

Mix one scoop with one cup (8fl oz) water. This can be taken either with or without meals. Take Cellular Skin Renewal daily. For enhanced synergistic effects, combine with Longevity Foundation AM/PM.

+ behavioral protocol

Protect your skin from the sun by applying mineral-based sunscreen. Avoid excess sugars, get sufficient sleep, and employ stress management techniques. Stay hydrated by drinking ample water. Avoid smoking or vaping, as these habits can lead to premature skin aging.

+ WARNING

Not recommended for use by children, or by pregnant or nursing women. Before using, it is advised to consult with a healthcare provider, especially if you are currently taking medication or have any chronic medical conditions. This product is not suitable for individuals who are allergic or hypersensitive to any component of the formula.

9 research-backed ingredients

Cellular Skin Renewal is made with powerful ingredients that have been shown in multiple studies to support skin health and trigger rejuvenation.

Collagen Peptides (VERISOL®)

2,500 mg

Collagen naturally declines with age, causing wrinkles, sagging, and dryness. VERISOL® collagen peptides are clinically proven to specifically stimulate your skin’s own collagen production, visibly reducing wrinkles, boosting elasticity, and improving hydration and firmness (2,4,5). Unlike typical collagen supplements—which are broken down into general-use proteins—VERISOL® uniquely activates skin’s collagen-producing cells, delivering real results for smoother skin, stronger nails, and thicker, healthier hair (2,4,5).
All references

Niacinamide (NAD+ Booster)

500 mg

Niacinamide (Vitamin B3) is an NAD+ booster clinically studied to visibly smooth fine lines and wrinkles, enhance elasticity, and reduce hyperpigmentation—restoring evenness and radiance (61). It stimulates collagen and ceramide production to strengthen your skin’s natural barrier, keeping your complexion healthy and hydrated (8,61-64). Niacinamide boosts essential NAD+ levels, crucial for youthful skin energy and repair (8,62-64).
All references

Hyaluronic acid

150 mg

Hyaluronic Acid (HA)—nature’s moisture magnet—dramatically improves hydration, visibly reducing fine lines and wrinkles (10,11). Because topical HA molecules are too large to penetrate beyond your skin’s surface, they can’t effectively hydrate or boost collagen production (10,65). Oral supplementation ensures HA reaches deep into your skin’s internal layers, enhancing elasticity and firmness. A daily dose of 150 mg is recommended for optimal skin health (10, 65). To obtain 150 mg of HA from bone broth, you would need to consume approximately 15-50 cups (3.6-12 liters) of bone broth.
All references

Astaxanthin (AstaZine®)

3.5 mg

Astaxanthin, found naturally in red marine life (like salmon and krill), offers potent protection from sun damage by neutralizing harmful UV-induced free radicals and inflammation—acting as your internal sunblock (36,37). Clinically proven to improve skin hydration, reduce wrinkles, and enhance overall tone (29,36,37), AstaZine® is an organic, highly bioavailable form derived from microalgae, offering unmatched antioxidant defense backed by over 200 FDA-recognized health benefits.
All references

Ceramides (CeraLOK®)

40 mg

Ceramides are essential lipids naturally found in your skin barrier, locking in moisture and keeping your skin plump and smooth. Aging depletes ceramides, leading to dryness, roughness, and wrinkles. CeraLOK®—clinically validated for superior absorption and effectiveness—replenishes your skin’s natural ceramide levels, visibly improving hydration, smoothing fine lines, and restoring brightness (3,31,57). Uniquely enhanced with β-sitosterol-3-O-glucoside for maximum potency, CeraLOK® delivers noticeable results for younger, softer skin (3,31,57).
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Spermidine

1 mg

Spermidine, a naturally occurring polyamine, has garnered attention for its remarkable impact on skin longevity. Its role in enhancing autophagy (the cellular process of self-cleaning) is crucial for maintaining the health and vitality of skin cells. By promoting the removal of damaged cells, spermidine may help slow down the skin's ageing process. This effect is further bolstered by its ability to stimulate collagen production, a key element in preserving skin elasticity and firmness. Additionally, its antioxidant properties provide a shield against oxidative stress, a major contributor to skin aging (9, 22).
All references

N-acetyl-D-glucosamine - NAG

500 mg

NAG visibly brightens your complexion, reduces wrinkles, and actively stimulates your body’s natural hyaluronic acid production for deeper hydration and youthful plumpness (58,59). It also combats glycation—preventing harmful sugar molecules from binding to elastin fibers, thus preserving elasticity and firmness (58). Since NAG is rarely found in common foods, supplementation is the easiest way to achieve brighter, smoother, and more youthful skin (58,59).
All references

Vitamin C

150 mg

Vitamin C (ascorbic acid) is one of skincare’s most scientifically proven antioxidants. It actively triggers collagen production, improving firmness and elasticity, and helps diminish fine lines, wrinkles, and age spots for smoother, brighter skin (7,35,51). As an essential nutrient, your body can't produce Vitamin C on its own—making daily supplementation crucial for visibly youthful, healthy skin.
All references

Vitamin E

30 mg

Vitamin E is a powerful antioxidant clinically proven to protect skin from damaging free radicals and UV-related stress, with enhanced protective effects when combined with Vitamin C and carotenoids (34). It significantly boosts hydration, reduces sun-induced inflammation, and promotes skin healing (52,53). Supplementation makes it easy to reach effective levels daily—without eating the equivalent of 10 avocados or 15 red bell peppers (52,53).
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Your 12 month journey with Cellular Skin Renewal

2 weeks

Initial hydration boost

Initial hydration boost leaves skin feeling softer and more supple. Subtle improvement in skin texture as moisture levels stabilize.

6 weeks

Increase Collagen

Fine lines begin to diminish as collagen production begins to take effect. Increased elasticity and firmness begins to take hold in targeted areas.

3 months

Reduce Wrinkles

Significant reduction in the appearance of wrinkles and fine lines. Improved skin barrier strength, reducing dryness and irritation. Nail & hair growth begin to improve.

6 months

Renewed Skin

Skin feels noticeably thicker and firmer, with enhanced resilience. Deeper hydration and reduced redness or uneven texture. Renewed skin vibrancy, giving a youthful, glowing appearance.

12 months

Long-Term Radiance

Consistent reduction in signs of aging, including wrinkles and sagging. Dramatic improvement in overall skin health, elasticity, and tone. Sustained skin vitality as senescent cells are purged and collagen production is optimized.

Skin is one of the most important and complex organs, essential for human longevity. With the frontline of longevity science, we are finally able to address its various mechanisms of deterioration, and create a portfolio approach to truly intervene and even reverse aspects of skin aging.

Francois Xavier Pellay, PhD. Longevity molecule hunter, and world renowned skin longevity expert.

Founded in Oxford - we’ve done our homework

At Jung+, we're on a crusade to liberate human longevity, translating the latest scientific advancements in aging research into products and technologies that can slow aging and extend healthy lifespan

Our scientists

GMP certified

Manufactured in facilities that follow Good Manufacturing Practices (GMP), ensuring the highest quality and purity.

Scientist Approved

Formulated by experts and rigorously evaluated by scientists to ensure effectiveness and safety.

Clinical-Grade Dosage

Contains the precise dosages used in clinical studies, ensuring you receive the optimal amount for maximum benefit.

Made in the USA

Proudly produced in the USA, ensuring adherence to the highest standards of quality and safety.

Meet our JUNG+ community

“I've researched it all: Jung delivers the best”

“Feeling younger, stronger, and more vibrant every single day”

“Longevity never felt so effortless— I'm obsessed with these products!”

FAQ’s

  • How should I take Cellular Skin Renewal?

    Mix one scoop with one cup (8fl oz) water. This can be taken either with or without meals. Take Cellular Skin Renwal daily. For enhanced synergistic effects, combine with Longevity Foundation AM/PM.

  • Are there any known side effects?

    The ingredients in Cellular Skin Renewal are typically well-tolerated, but individual responses may differ. As with any dietary supplement, seeking advice from your healthcare professional before initiating a new supplement regimen is advisable. This is particularly important if you have underlying medical conditions or are taking medications, and consulting with a healthcare professional ensures personalized guidance and compatibility with your circumstances.

  • How long does it take to see results with Cellular Skin Renewal?

    Results may vary depending on individual factors such as overall health, lifestyle, and genetics. Consistent use of the Cellular Skin Renewal, along with a healthy diet and skincare routine, can contribute to visible improvements in the skin's appearance over time. However, with consistent use, many have reported positive results in as little as 4 weeks, and as long as 3 months.

  • Does Cellular Skin Renewal replace a healthy skincare routine?

    Cellular Skin Renewal is designed to complement a healthy skincare routine, not replace it. While the supplement can provide essential nutrients to support skin health, it is important to maintain a comprehensive skincare regimen that includes healthy diet, adequate hydration, sun protection, avoiding smoking and high sugar foods, and other skincare practices suitable for your skin type and concerns.

  • Can Cellular Skin Renewal cure skin conditions or diseases?

    Cellular Skin Renewal is a dietary supplement not intended to diagnose, treat, cure, or prevent skin conditions or diseases. If you have specific skin concerns or medical conditions, it is important to consult with a dermatologist or healthcare professional for proper diagnosis and treatment.

  • Can I take Cellular Skin Renewal if I'm already taking other skincare supplements?

    It is generally safe to take Cellular Skin Renewal alongside other skincare supplements. However, consulting with a healthcare professional or pharmacist is recommended to ensure no potential interactions between the different supplements you are taking.

  • What else can I do to enhance the effectiveness of Cellular Skin Renewal.

    Cellular Skin Renewal is designed to be stackable and have powerful synergistic effects with Longevity Foundation AM/PM. We also recommend protecting your skin from the sun by applying mineral-based sunscreen. Ensure a balanced diet, sufficient sleep, and effective stress management. Stay hydrated by drinking ample water. Avoid smoking or vaping, as these habits can lead to premature skin aging.

Developed by experts

Dr. Sagner is a world leading human performance specialist, sports and preventive medicine, and was the medical director at Europe’s first University medical center section for preventive medicine and lifestyle medicine. Dr Sagner is a member of the European Union Platform for Action on Diet, Physical Activity and Health and a partner of the European Innovation Partnership on Active and Healthy Aging.

Dr. Michael Sagner, MD

DIRECTOR, EUROPEAN SOCIETY OF PREVENTIVE MEDICINE
Francois-Xavier Pellay, PhD, known as the 'Longevity Molecule Hunter', is a world leading scientist and entrepreneur in the longevity industry. Pellay is a multidisciplinary scientist with a background which includes a Master's degree in Biochemistry, a Master's degree in Organic Chemistry, a Ph.D. in Bioinformatics and years of expertise in Microbiology, Molecular Biology, Cellular Biology and Biology of Aging.

Francois-Xavier Pellay, PhD

PROFESSOR | SCIENTIST | LONGEVITY MOLECULE HUNTER | FOUNDER, BIMINI BIOTECH
Dr. Fady Hannah-Shmouni, MD FRCPC, is a physician-investor at the forefront of endocrinology, genomics, and healthspan medicine. As a distinguished Professor at the University of British Columbia, he passionately empowers individuals by facilitating access to groundbreaking technologies in precision medicine, including artificial intelligence and genomic advancements.

Dr. Fady Hannah-Shmouni

LONGEVITY PHYSICIAN | PROFESSOR | YALE SCHOOL OF MEDICINE | NIH | UNIVERSITY OF BRITISH COLUMBIA
Dr. Avi Roy is an accomplished biomedical scientist, mentor, and entrepreneur with a deep-rooted passion for advancing the field of longevity. His academic journey culminated in a PhD from the University of Oxford. With over 15 years of dedicated research and development in the longevity sector, Dr. Roy has established himself as a a leading figure in this dynamic and ever-evolving field. As a mentor and investor in health-tech startups, he continues to inspire and guide the next generation of scientists and entrepreneurs.

Avi Roy

BIOMEDICAL SCIENTIST | INVENTOR | UNIVERSITY OF OXFORD | FOUNDER, UDA

Scientific studies

  • Reduction in Skin Wrinkles & Fine Lines with Verisol Collagen Peptides

    This study explored the effects of Verisol collagen peptides on skin wrinkle reduction and dermal matrix synthesis in a randomized, double-blind, placebo-controlled trial. A total of 114 women aged 45–65 were assigned to receive 2.5 g of collagen peptides or a placebo daily for 8 weeks. Wrinkle depth was measured at baseline and at the study's conclusion, while biomarkers such as procollagen type I, elastin, and fibrillin were also assessed. Results revealed a 20% reduction in eye wrinkle depth after 8 weeks of supplementation. Biomarker analysis indicated significant increases in procollagen type I levels by 65%, elastin by 18%, and fibrillin by 6%, demonstrating enhanced dermal matrix synthesis and overall skin rejuvenation. The study confirmed Verisol's efficacy in visibly reducing wrinkles and supporting skin health at a biological level. (25)

  • Oral versus topical Vitamin C for skin health

    The study highlights the significant impact of Vitamin C on skin health, underscoring its essential role in the synthesis of collagen, a vital component for maintaining skin structure and elasticity. Vitamin C, a powerful antioxidant, also aids in protecting the skin from oxidative stress caused by UV radiation and environmental pollutants, which can lead to premature aging. Importantly, the study emphasizes the superiority of oral supplementation of Vitamin C over topical application. This is primarily because oral intake ensures a more consistent distribution of the nutrient throughout the body, including the skin. In contrast, the effectiveness of topical application is limited due to the challenges in penetrating the skin barrier and achieving adequate concentrations in the dermis. The study concludes that oral supplementation of Vitamin C is a more efficient method for enhancing skin health, promoting better collagen synthesis, and offering comprehensive protection against oxidative damage (7).

  • Ingestion of hydrolyzed collagen for 90 days is effective in reducing skin aging.

    Hydrolyzed collagen supplementation has shown positive effects on human skin aging. A systematic review and meta-analysis of 19 clinical trials revealed that oral intake of hydrolyzed collagen for 90 days resulted in reduced skin wrinkles and improved skin hydration, elasticity, and firmness. The study involved 1,125 participants aged 20 to 70 years, predominantly women. Overall, the findings support the effectiveness of hydrolyzed collagen in combating skin aging (4).

  • Verisol Collagen Peptides Improve Skin Elasticity: A Double-Blind, Placebo-Controlled Study"

    This study evaluated the effects of Verisol collagen peptides on skin elasticity in 69 women aged 35–55. Participants were randomized into three groups receiving either 2.5 g, 5.0 g of collagen peptides, or a placebo daily for 8 weeks. Skin elasticity, the primary outcome, was measured at baseline, 4 weeks, and 8 weeks, with a follow-up 4 weeks after supplementation ceased. Results showed significant improvements in skin elasticity for both collagen groups compared to placebo, with a 7% increase after 8 weeks and a 6% sustained improvement 4 weeks post-supplementation. No adverse effects were reported, highlighting the safety and efficacy of collagen supplementation. (4)

  • Ceramides supplementation improves skin aging by supporting the skin's natural barrier function.

    Ceramides are vital to the skin's lipid barrier, maintaining hydration and protecting against external stressors. Replenishing ceramide levels through supplementation helps strengthen the skin barrier, reducing transepidermal water loss and improving skin moisture levels. This can lead to improved skin elasticity, decreased roughness, and reduce visible signs of aging (68).

  • Cosmeceuticals containing vitamins C, E, and niacinamide are increasingly important in skin care.

    Cosmeceuticals refer to products containing active substances that fall outside the categorization of cosmetics or drugs. Among these, those with vitamins C, E, and B3 have demonstrated potential benefits for mitigating skin aging. Vitamin C is known for its antioxidant properties and ability to stimulate collagen production, reducing wrinkle appearance and enhancing skin elasticity. Vitamin E also functions as an antioxidant, safeguarding the skin against damage caused by free radicals. Vitamin B3, also known as niacinamide, has positively enhanced the skin's protective barrier, minimized hyperpigmentation, and refined skin texture. (33, 67).

  • Long-term prophylactic astaxanthin supplementation may inhibit age-related skin deterioration and maintain skin conditions associated with environmentally induced damage

    Astaxanthin, a potent antioxidant, and anti-inflammatory carotenoid, was evaluated for its anti-inflammatory effects on skin deterioration. In vitro, experiments demonstrated that astaxanthin reduced inflammatory cytokine secretion in keratinocytes and matrix metalloproteinase-1 secretion in UVB-irradiated fibroblasts. A 16-week clinical study involving 65 healthy female participants found that oral administration of astaxanthin (6 mg or 12 mg) prevented the worsening of wrinkle parameters and skin moisture content compared to the placebo group. Additionally, interleukin-1α levels in the stratum corneum increased in the placebo and low-dose groups but not in the high-dose group (36).

  • N-acetyl-D-glucosamine is a hyaluronic acid precursor accelerating wound healing, improving skin hydration, and decreasing wrinkles.

    N-Acetyl-D-glucosamine (NAG) is a naturally occurring form of glucosamine that is structurally analogous to components found in the human body. Its bioavailability, or the ease with which the body can absorb and utilize it, is reported to be three times greater than other forms of glucosamine. Glucosamine and its derivative, N-acet-D-glucosamine, have important bodily functions, including the synthesis of hyaluronic acid and proteoglycans (69). They have been shown to provide various benefits for the skin, such as promoting wound healing, improving skin hydration, reducing wrinkles, and inhibiting melanin production for hyperpigmentation treatment (59).

  • Recovery of Human Dermal Structure and Barrier Function Induced by Spermidine through the Skin Microbiome.

    This study reveals the significant role of Streptococcus species, particularly S. pneumoniae, S. infantis, and S. thermophilus, in improving skin structure and barrier function, contributing to anti-aging. The numbers of these bacteria is higher in younger individuals or those with more elastic skin, and their secretions, especially spermidine, enhance collagen and lipid synthesis in aged cells. These findings highlight the potential of leveraging the skin microbiome, particularly Streptococcus-secreted compounds like spermidine, in developing anti-aging skincare treatments (9).

  • The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging

    NAD (Nicotinamide Adenine Dinucleotide) plays a crucial role in maintaining skin health and combating aging. Daily environmental factors, especially solar radiation, induce oxidative stress, disrupting skin's normal functioning and accelerating aging. This stress depletes NAD+ and ATP levels, affecting cellular energy and leading to chronic damage, particularly in mitochondria. NAD+ and its precursor, nicotinamide, are key to skin homeostasis. They are linked to dietary requirements and are beneficial in treating inflammatory conditions, preventing photoaging, and reducing cancer risk. Aged skin shows lower NAD+ levels, and nicotinamide supplementation can help restore these, mitigating energy dysfunction. It protects dermal fibroblasts from oxidative damage, enhances mitochondrial efficiency, and supports selective mitophagy through sirtuin activation. NAD+ levels are dynamic, influencing cellular metabolism, mitochondrial function, and circadian rhythms. Understanding NAD+'s role in skin biology is vital for developing interventions to maintain skin health and cellular bioenergetics, especially against UV-induced stress (14).

  • Induction of autophagy by spermidine promotes longevity

    Spermidine, a natural polyamine found to decline with age, has emerged as a significant factor in promoting longevity. This groundbreaking study reveals that spermidine supplementation remarkably extends the lifespan of yeast, flies, worms, and even human immune cells. Moreover, it offers potent protection against oxidative stress in aging mice. The key to spermidine's efficacy lies in its ability to induce epigenetic changes, particularly the deacetylation of histone H3. This process, driven by the inhibition of histone acetyltransferases (HAT), leads to reduced oxidative stress and necrosis in aging yeast. On the flip side, reduced levels of endogenous polyamines correlate with increased acetylation, reactive oxygen species production, early necrotic death, and a shortened lifespan. Spermidine's impact extends to upregulating autophagy-related transcripts, thereby triggering autophagy in various organisms and human cells. This enhanced autophagy is essential for spermidine's role in suppressing necrosis and boosting longevity, underscoring its potential as a powerful anti-aging intervention (22).

  • Oral intake of VERISOL® reduces skin wrinkles and increases dermal matrix synthesis

    VERISOL®, a specific bioactive collagen peptide (BCP), has been clinically proven to be effective in reducing skin aging, particularly eye wrinkle formation. In a rigorous double-blind, placebo-controlled study involving 114 women aged 45-65, participants receiving 2.5 g of VERISOL® daily for 8 weeks showed a significant reduction in eye wrinkle volume. Notably, this effect persisted even four weeks after ceasing intake, highlighting its lasting benefits. Beyond just wrinkle reduction, VERISOL® remarkably enhanced the skin's internal structure. After 8 weeks of consistent use, there was a substantial increase in the skin's procollagen type I content by 65% and elastin by 18%, compared to those on a placebo. These components are crucial for maintaining skin elasticity and firmness. Although the increase in fibrillin was a modest 6%, VERISOL®'s overall impact on enhancing dermal matrix synthesis is evident. These findings underscore VERISOL®'s efficacy in not only visibly reducing wrinkles but also improving the skin's overall health and youthful appearance from within (25).

  • The role of vitamin E in normal and damaged skin.

    Vitamin E is a crucial antioxidant for skin health, particularly in combating the damaging effects of oxidative stress, including photoaging. This stress, often triggered by environmental factors like UV light, can lead to various skin issues such as wrinkles, inflammation, and even skin cancer. Vitamin E's potent antioxidative and anti-inflammatory properties help protect the skin from these harmful effects. Its effectiveness is well-documented through animal studies, human skin tests, and biochemical investigations, emphasizing its vital role in maintaining skin health and potentially treating various skin disorders. The development of effective systemic and local Vitamin E-based treatments is essential for harnessing its skin-protective benefits (34).

  • Systematic Review on the Effects of Astaxanthin on Human Skin Aging

    Astaxanthin (ASX), is known for its potent antioxidant and anti-inflammatory effects, which have shown promise in mitigating skin photoaging and age-related skin diseases. A comprehensive analysis of eleven studies, including nine randomized controlled trials and two open-label studies, revealed that oral supplementation of ASX significantly improved skin moisture and elasticity. The studies suggest that ASX, when ingested or applied topically, can effectively reduce signs of skin aging, enhancing moisture content, elasticity, and reducing wrinkles and sebum oil. The findings support ASX's potential as a beneficial ingredient in cosmeceutical products aimed at delaying and improving signs of skin aging (37).

  • Improvement of Hair Thickness with Verisol Collagen Peptides

    This study evaluated the effects of Verisol collagen peptides on hair thickness and overall hair health. Conducted as a randomized, double-blind trial, participants consumed 2.5 g of Verisol collagen peptides daily for 16 weeks. Hair thickness and follicle cell proliferation were assessed through both in vivo and in vitro methods. Results showed an 11% increase in hair diameter after 16 weeks of supplementation, indicating visibly thicker hair. Additionally, in vitro analysis revealed a 31% increase in hair follicle cell proliferation, demonstrating Verisol's ability to positively influence the biological processes underlying hair growth. The findings suggest that Verisol collagen peptides can significantly improve hair structure and volume when taken consistently.

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